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Phospholipase A2 (PLA2) activity was measured in articular cartilage from normal and osteoarthritic (OA) human femoral heads. Protoglycanase and collagenase activity was determined in the same specimens using radiolabelled human proteoglycan subunit and type II collagen, respectively. Grossly normal and fibrillated OA cartilage samples showed a significant increase in PLA2 activity which was not found in osteophytic cartilage. PLA2 activity was found to be correlated with proteoglycanase but unrelated to collagenase activity. Tiaprofenic acid induced in vitro a concomitant increase in PLA2 and a decrease in proteoglycanase activity. PLA2 which may be activated by cytokines as well as mechanical factors is suggested as a key enzyme in chondrocyte metabolism regulation. Tiaprofenic acid is shown as a potential chondroprotective nonsteroidal anti-inflammatory drug.
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
January 1991,
FEBS letters,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
March 1997,
Osteoarthritis and cartilage,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
January 2011,
Scandinavian journal of rheumatology,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
January 1991,
Life sciences,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
April 1990,
The Journal of rheumatology,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
January 1983,
Arthritis and rheumatism,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
January 1990,
Advances in experimental medicine and biology,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
November 1990,
Arthritis and rheumatism,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
July 1973,
The Journal of bone and joint surgery. American volume,
E Vignon, and
P Mathieu, and
P Louisot, and
J Vilamitjana, and
M F Harmand, and
M Richard
April 1973,
Federation proceedings,
