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Perfluorononanoic acid (PFNA) is a ubiquitous and persistent environmental contaminant. Although its levels in the environment and in humans are lower than those of perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA), a steady trend of increases in the general population in recent years has drawn considerable interest and concern. Previous studies with PFOS and PFOA have indicated developmental toxicity in laboratory rodent models. The current study extends the evaluation of these adverse outcomes to PFNA in mice. PFNA was given to timed-pregnant CD-1 mice by oral gavage daily on gestational day 1-17 at 1, 3, 5 or 10mg/kg; controls received water vehicle. Dams given 10mg/kg PFNA could not carry their pregnancy successfully and effects of this dose group were not followed. Similar to PFOS and PFOA, PFNA at 5mg/kg or lower doses produced hepatomegaly in the pregnant dams, but did not affect the number of implantations, fetal viability, or fetal weight. Mouse pups were born alive and postnatal survival in the 1 and 3mg/kg PFNA groups was not different from that in controls. In contrast, although most of the pups were also born alive in the 5mg/kg PFNA group, 80% of these neonates died in the first 10 days of life. The pattern of PFNA-induced neonatal death differed somewhat from those elicited by PFOS or PFOA. A majority of the PFNA-exposed pups survived a few days longer after birth than those exposed to PFOS or PFOA, which typically died within the first 2 days of postnatal life. Surviving neonates exposed to PFNA exhibited dose-dependent delays in eye opening and onset of puberty. In addition, increased liver weight seen in PFNA-exposed offspring persisted into adulthood and was likely related to the persistence of the chemical in the tissue. Evaluation of gene expression in fetal and neonatal livers revealed robust activation of peroxisome proliferator-activated receptor-alpha (PPARĪ±) target genes by PFNA that resembled the responses of PFOA. Our results indicate that developmental toxicity of PFNA in mice is comparable to that of PFOS and PFOA, and that these adverse effects are likely common to perfluoroalkyl acids that persist in the body.
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
March 1994,
Research communications in chemical pathology and pharmacology,
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
October 2008,
Toxicological sciences : an official journal of the Society of Toxicology,
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
April 1989,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
February 1992,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
January 2013,
Clinical & experimental pharmacology,
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
January 1998,
Reproductive toxicology (Elmsford, N.Y.),
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
January 2019,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
December 2019,
Journal of applied toxicology : JAT,
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
March 2018,
Toxicological sciences : an official journal of the Society of Toxicology,
Kaberi P Das, and
Brian E Grey, and
Mitchell B Rosen, and
Carmen R Wood, and
Katoria R Tatum-Gibbs, and
R Daniel Zehr, and
Mark J Strynar, and
Andrew B Lindstrom, and
Christopher Lau
November 1994,
Environmental health perspectives,
