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[Clinicopathological characteristics, diagnosis and treatment of Castleman's disease]. 2014

Xibo Fu, and Qingcai Fu, and Xiangdong Hua, and Zuohong Ma, and Liang Zhang, and Yuming Wang, and Da Chi, and Peifang Ning
Department of Hepatobiliary Surgery, Liaoning Cancer Hospital, Shenyang 110042, China. Email: fuxibo@sina.com.

OBJECTIVE To explore the clinicopathological characteristics, diagnosis and treatment of Castleman's disease. METHODS Seven teen cases of castleman's disease confirmed by surgery and pathology were presented, with the helping of relevant literatures, to discuss its clinical presentation, CT findings, pathology, diagnosis, treatment and prognosis, especially the cases with PNP. RESULTS There were 10 males and 7 females with an age range of 28-56 years. They were all of local hyaline-vascular types according to histopathology. All cases were cured by surgical resection. CONCLUSIONS Castleman's disease is a rare lyphoproliferative disorder with giant lymph node hyperplasia. Its diagnosis depends on its histopathological characteristics and clinical manifestations should also be taken into account. Surgical resection is the first choice and other treatments may be effective.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260 Female Females
D005871 Castleman Disease Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A. Angiofollicular Lymphoid Hyperplasia,Castleman's Tumor,Giant Lymph Node Hyperplasia,Hyperplasia, Giant Lymph Node,Lymph Node Hyperplasia, Giant,Angiofollicular Lymph Hyperplasia,Angiofollicular Lymph Node Hyperplasia,Castleman's Disease,Castlemans Disease,Angiofollicular Lymph Hyperplasias,Angiofollicular Lymphoid Hyperplasias,Castleman Tumor,Castlemans Tumor,Disease, Castlemans,Hyperplasia, Angiofollicular Lymph,Hyperplasia, Angiofollicular Lymphoid,Lymph Hyperplasia, Angiofollicular,Lymphoid Hyperplasia, Angiofollicular,Tumor, Castleman's
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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