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Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. 2015
Christa J Van Dort, and
Daniel P Zachs, and
Jonathan D Kenny, and
Shu Zheng, and
Rebecca R Goldblum, and
Noah A Gelwan, and
Daniel M Ramos, and
Michael A Nolan, and
Karen Wang, and
Feng-Ju Weng, and
Yingxi Lin, and
Matthew A Wilson, and
Emery N Brown
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; and Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, vandortc@mit.edu enb@neurostat.mit.edu.
Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep.
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