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Transient antiphospholipid syndrome associated with primary cytomegalovirus infection: a case report and literature review. 2014
Tsuyoshi Nakayama, and
Mitsuteru Akahoshi, and
Kensuke Irino, and
Yasutaka Kimoto, and
Yojiro Arinobu, and
Hiroaki Niiro, and
Hiroshi Tsukamoto, and
Takahiko Horiuchi, and
Koichi Akashi
Department of Clinical Immunology and Rheumatology/Infectious Disease, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Viral infection is known to induce transient autoimmunity in humans. Acute cytomegalovirus (CMV) infection is implicated in occasional thrombosis formation. We here, for the first time, report a 19-year-old female who had an acute CMV infection, leading to a deep venous thrombosis and a pulmonary embolism along with transient appearance of lupus anticoagulant. The pathological role of antiphospholipid antibodies in CMV-mediated thrombosis is discussed.
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