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We measured levels of cartilage proteoglycan (PG) fragments in knee joint synovial fluid obtained from patients with previous trauma of the knee, early gonarthrosis, or pyrophosphate synovitis, and in age-matched control subjects. During the initial 3-4 weeks after rupture of the anterior cruciate ligament or the meniscus (confirmed by arthroscopy), markedly increased PG fragment levels were found. At later times after trauma (up to 4 years), many of these patients still had significantly elevated levels of cartilage PG fragments in the joint fluid. In a group of older patients with gonarthrosis, these levels were only moderately elevated, while in patients with acute pseudogout, greatly increased levels were observed. Although longitudinal studies are needed to validate the significance, PG fragments in joint fluid may be a marker for early posttraumatic arthrosis.
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
January 1995,
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
January 1988,
Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
January 1997,
Journal of pediatric orthopedics,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
September 1996,
Annals of the rheumatic diseases,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
January 1998,
Osteoarthritis and cartilage,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
June 1993,
Acta orthopaedica Scandinavica,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
July 1993,
Journal of biomedical materials research,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
July 1995,
Arthritis and rheumatism,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
February 1993,
Biomaterials,
L S Lohmander, and
L Dahlberg, and
L Ryd, and
D Heinegård
February 1993,
Arthritis and rheumatism,
