-transparent.png){kind=logo}
The effect of intravenous injections of 5-, 12- and 15-hydroxyeicosatetraenoic acids (HETE), leukotrienes D4 and E4 (LTD4, LTE4) on tracheal mucous gel layer (TMGL) thickness was assessed in rats. When administered in doses ranging from 0.03 pg to 33 ng per rat, the lipoxygenase metabolites produced significant increases in TMGL thickness. The order of potency of the metabolites was 15-HETE greater than 12-HETE greater than or equal to 5-HETE greater than LTD4 greater than or equal to LTE4. Imidazole (31.6 mg/kg), intravenously, significantly decreased this response. These findings suggest that the mono-HETEs, especially 15-HETE, may be important modulators of airway mucus in the rat.
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
January 1986,
Prostaglandins,
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
January 1984,
Investigative radiology,
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
September 1999,
Japanese journal of pharmacology,
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
January 1962,
Anesthesia and analgesia,
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
June 1997,
Asia Pacific journal of clinical nutrition,
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
January 1946,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
May 1974,
Prostaglandins,
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
January 1978,
Neurologia i neurochirurgia polska,
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
February 1972,
The American journal of clinical nutrition,
J M Yanni, and
M H Foxwell, and
L L Whitman, and
W L Smith, and
J C Nolan
April 1954,
Journal of the American Medical Association,
