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Efficacy and safety of a low molecular weight heparin (Alfa LMWH) was compared with unfractionated heparin (UFH) in the prevention of post-operative venous thromboembolism after hip fractures. Forty-nine patients were randomized to treatment with Alfa LMWH 7500 anti-Xa coagulometric units twice daily or with UFH 5000 IU t.i.d. Screening for thrombosis was performed with 125-I-fibrinogen leg scanning and strain-gauge plethysmography. Positive results were confirmed by venography. Five patients in the Alfa LMWH group (20 per cent) developed venographycally proven deep vein thrombosis (DVT) versus seven (29 per cent) in the UFH group. One pulmonary embolism and two deaths occurred in the UFH group and none in the LMWH group. No differences in haemorrhagic complications and blood loss indices were observed. Alfa LMWH appears to be a promising drug for prevention of venous thromboembolism after orthopaedic surgery. A "flexible" schedule of administration is proposed on the basis of the results of plasma anti-Xa assays.
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
September 1991,
BMJ (Clinical research ed.),
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
April 1991,
Annals of internal medicine,
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
February 1988,
The British journal of surgery,
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
January 1992,
World journal of surgery,
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
April 1991,
The Journal of bone and joint surgery. American volume,
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
July 1993,
Archives of internal medicine,
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
July 2001,
Anales de medicina interna (Madrid, Spain : 1984),
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
January 2006,
Acta cirurgica brasileira,
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
December 1993,
Annals of internal medicine,
M Pini, and
A Tagliaferri, and
C Manotti, and
F Lasagni, and
E Rinaldi, and
A G Dettori
September 2010,
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery,
