Effect of cerebellar transcranial magnetic stimulation on soleus Ia presynaptic and reciprocal inhibition. 2015

Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
aFaculty of Rehabilitation, Shijonawate Gakuen University bDepartment of Rehabilitation, Yamamoto Hospital, Wakayama cCenter for Information and Neural Networks, National Institute of Information and Communications Technology dJapan Society for the Promotion of Science, Tokyo eRehabilitation Unit, Osaka University Hospital, Osaka fDepartment of Rehabilitation, Hannachuo Hospital gFaculty of Health Science, Kio University hNeurorehabilitation Research Center of Kio University, Nara iDepartment of Rehabilitation for Intractable Neurological Disorders, Institute of Brain and Blood Vessels Mihara Memorial Hospital, Gunma, Japan.

Previously, we reported that cerebellar transcranial magnetic stimulation (C-TMS) facilitates spinal motoneuronal excitability in resting humans. In this study, we aimed to characterize the descending pathway that is responsible for the C-TMS-associated cerebellar spinal facilitation. We evaluated the effect of C-TMS on ipsilateral soleus Ia presynaptic inhibition (PSI) and reciprocal inhibition (RI) because the vestibulospinal and reticulospinal tracts project from the cerebellum to mediate spinal motoneurons via interneurons associated with PSI. PSI and RI were measured with a soleus H-reflex test following operant conditioning using electrical stimulation of the common peroneal nerve. C-TMS was delivered before test tibial nerve stimulation with conditioning-test interstimulus intervals of 110 ms. C-TMS did not generate motor-evoked potentials, and it did not increase electromyography activity in the ipsilateral soleus muscle, indicating that C-TMS does not directly activate the corticospinal tract and motoneurons. However, C-TMS facilitated the ipsilateral soleus H-reflex and reduced the amount of soleus Ia PSI, but not RI. These findings indicate that C-TMS may facilitate the excitability of the spinal motoneuron pool via the vestibulospinal or reticulospinal tracts associated with PSI. Cerebellar spinal facilitation may be useful for assessing the functional connectivity of the cerebellum and vestibular nuclei or reticular formation.

UI MeSH Term Description Entries
D009046 Motor Neurons Neurons which activate MUSCLE CELLS. Neurons, Motor,Alpha Motorneurons,Motoneurons,Motor Neurons, Alpha,Neurons, Alpha Motor,Alpha Motor Neuron,Alpha Motor Neurons,Alpha Motorneuron,Motoneuron,Motor Neuron,Motor Neuron, Alpha,Motorneuron, Alpha,Motorneurons, Alpha,Neuron, Alpha Motor,Neuron, Motor
D010543 Peroneal Nerve The lateral of the two terminal branches of the sciatic nerve. The peroneal (or fibular) nerve provides motor and sensory innervation to parts of the leg and foot. Fibular Nerve,Fibular Nerves,Nerve, Fibular,Nerve, Peroneal,Nerves, Fibular,Nerves, Peroneal,Peroneal Nerves
D011712 Pyramidal Tracts Fibers that arise from cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord. Many authorities say the pyramidal tracts include both the corticospinal and corticobulbar tracts. Corticobulbar Tracts,Corticospinal Tracts,Decussation, Pyramidal,Corticobulbar Tract,Corticospinal Tract,Pyramidal Decussation,Pyramidal Tract,Tract, Corticobulbar,Tract, Corticospinal,Tract, Pyramidal,Tracts, Corticobulbar,Tracts, Corticospinal,Tracts, Pyramidal
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D003216 Conditioning, Operant Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced. Instrumental Learning,Learning, Instrumental,Operant Conditioning,Conditionings, Operant,Instrumental Learnings,Learnings, Instrumental,Operant Conditionings
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D004576 Electromyography Recording of the changes in electric potential of muscle by means of surface or needle electrodes. Electromyogram,Surface Electromyography,Electromyograms,Electromyographies,Electromyographies, Surface,Electromyography, Surface,Surface Electromyographies
D006181 H-Reflex A monosynaptic reflex elicited by stimulating a nerve, particularly the tibial nerve, with an electric shock. H Reflex,H-Reflexes,H Reflexes,Reflex, H
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013979 Tibial Nerve The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot. Medial Plantar Nerve,Posterior Tibial Nerve,Medial Plantar Nerves,Nerve, Medial Plantar,Nerve, Posterior Tibial,Nerve, Tibial,Nerves, Medial Plantar,Nerves, Posterior Tibial,Nerves, Tibial,Plantar Nerve, Medial,Plantar Nerves, Medial,Posterior Tibial Nerves,Tibial Nerve, Posterior,Tibial Nerves,Tibial Nerves, Posterior

Related Publications

Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
August 2012, Experimental brain research,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
January 2001, Electromyography and clinical neurophysiology,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
March 2017, Somatosensory & motor research,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
December 1994, Journal of neurology, neurosurgery, and psychiatry,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
January 2017, Functional neurology,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
January 2020, Neuroscience research,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
April 1997, Electroencephalography and clinical neurophysiology,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
April 2002, Perceptual and motor skills,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
March 1993, Experimental physiology,
Akiyoshi Matsugi, and Nobuhiko Mori, and Shintaro Uehara, and Noriyuki Kamata, and Kosuke Oku, and Yohei Okada, and Yutaka Kikuchi, and Kouichi Mukai, and Kiyoshi Nagano
April 2001, Brain : a journal of neurology,
Copied contents to your clipboard!