-transparent.png){kind=logo}
A 65-year-old male was admitted to our hospital due to recurred malignant lymphoma of left tonsil origin. Studies using flow cytometry on mononuclear cells in peripheral blood revealed the appearance of intermediate B cells, and examinations on gastrointestinal tract showed diffuse infiltration of medium-sized lymphoid cells into stomach and colon, that had the same phenotype as tumor cells in peripheral blood. They suggested leukemic change and gastrointestinal tract infiltration of malignant lymphoma. Southern blot analysis revealed T-cell receptor beta-chain gene rearrangement as well as immunoglobulin gene rearrangement. Analysis by histo in situ hybridization on infiltrated gastric mucosa specimen showed diffuse expression of immunoglobulin mRNA in tumor cells, but no message of T-cell receptor beta-chain gene. Northern blot analysis showed the same result. It suggests that in this case, the rearrangement of T-cell receptor beta-chain gene is ineffective rearrangement without transcription to mRNA.
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
September 1985,
The Journal of experimental medicine,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
October 1993,
The Journal of veterinary medical science,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
December 1992,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
January 1990,
Oncology,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
March 2000,
Nihon rinsho. Japanese journal of clinical medicine,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
January 2018,
International journal of clinical and experimental pathology,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
January 1987,
Blood,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
January 2012,
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
September 2013,
World journal of gastroenterology,
H Takahashi, and
T Nakano, and
A Ono, and
T Higashide, and
T Sugiyama, and
K Imai, and
A Yachi
February 1986,
Onkologie,
