Synthesis of chromonylthiazolidines and their cytotoxicity to human cancer cell lines. 2015

Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, Vietnam. anh_792002@yahoo.com.

Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed. Compounds 3a and 3b showed the most selective cytotoxic effects against human epidermoid carcinoma (IC50 44.1 ± 3.6 μg/mL) and breast cancer (IC50 32.8 ± 1.4 μg/mL) cell lines, respectively. The results suggest that chromoylthiazolidines are potential low-cost, and selective anticancer agents.

UI MeSH Term Description Entries
D004354 Drug Screening Assays, Antitumor Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals. Anticancer Drug Sensitivity Tests,Antitumor Drug Screens,Cancer Drug Tests,Drug Screening Tests, Tumor-Specific,Dye Exclusion Assays, Antitumor,Anti-Cancer Drug Screens,Antitumor Drug Screening Assays,Tumor-Specific Drug Screening Tests,Anti Cancer Drug Screens,Anti-Cancer Drug Screen,Antitumor Drug Screen,Cancer Drug Test,Drug Screen, Anti-Cancer,Drug Screen, Antitumor,Drug Screening Tests, Tumor Specific,Drug Screens, Anti-Cancer,Drug Screens, Antitumor,Drug Test, Cancer,Drug Tests, Cancer,Screen, Anti-Cancer Drug,Screen, Antitumor Drug,Screens, Anti-Cancer Drug,Screens, Antitumor Drug,Test, Cancer Drug,Tests, Cancer Drug,Tumor Specific Drug Screening Tests
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D053778 Thiazolidines Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES. Thiazolidine
D021241 Spectrometry, Mass, Electrospray Ionization A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry. ESI Mass Spectrometry,Electrospray Ionization Mass Spectrometry,Mass Spectrometry, ESI,Spectrometry, ESI Mass
D066241 Carbon-13 Magnetic Resonance Spectroscopy Magnetic resonance spectroscopy involving detection of changes in the resonance of carbon-13 nuclei in organic molecules. 13C NMR,Carbon 13 Magnetic Resonance Spectroscopy
D066244 Proton Magnetic Resonance Spectroscopy Spectroscopy technique which measures changes in organic compounds by tracking the spectral energy of absorption of HYDROGEN atoms. 1H NMR,1H-MRS,1H-NMR

Related Publications

Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
July 2018, Chemistry & biodiversity,
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
May 2016, ACS combinatorial science,
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
February 2023, International journal of molecular sciences,
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
November 2022, Carbohydrate research,
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
May 2024, Chemistry & biodiversity,
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
October 2002, Archives of pharmacal research,
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
September 2019, Molecules (Basel, Switzerland),
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
March 2005, Archives of pharmacal research,
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
December 2018, Phytochemistry,
Hoang Le Tuan Anh, and Nguyen Thi Cuc, and Bui Huu Tai, and Pham Hai Yen, and Nguyen Xuan Nhiem, and Do Thi Thao, and Nguyen Hoai Nam, and Chau Van Minh, and Phan Van Kiem, and Young Ho Kim
December 2019, Biotechnology reports (Amsterdam, Netherlands),
Copied contents to your clipboard!