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Polymorphonuclear leukocyte (PMNL) infiltration is an important characteristic in psoriatic lesions. Elevated concentrations of the chemoattractant eicosanoid leukotriene B4 (LTB4) are present in psoriatic skin. Its chemotactic activity is mediated via high affinity receptors on PMNL. The goal of our work was to ascertain whether PMNL infiltration in psoriasis can be accounted for by functional abnormalities of the circulating PMNL due to alterations in the LTB4 receptor density or affinity (or both). No significant difference was found between patients with psoriasis, healthy controls and patients with another inflammatory dermatosis (atopic eczema) with regard to the binding parameters of LTB4 receptors on PMNL. Our findings suggest that PMNL accumulation in psoriatic skin may be the result of an excess of cutaneous chemoattractant rather than the increased readiness of psoriatic PMNL to migrate towards LTB4 due to altered LTB4 receptor density or affinity.
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
January 1985,
Advances in prostaglandin, thromboxane, and leukotriene research,
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
October 1982,
Lancet (London, England),
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
October 1986,
FEBS letters,
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
October 1990,
Sheng li ke xue jin zhan [Progress in physiology],
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
August 2002,
Prostaglandins & other lipid mediators,
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
October 1986,
Prostaglandins,
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
November 1988,
Journal of immunology (Baltimore, Md. : 1950),
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
December 1984,
Prostaglandins,
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
July 2006,
Fukuoka igaku zasshi = Hukuoka acta medica,
F Meier, and
E Gross, and
K N Klotz, and
T Ruzicka
January 1991,
Agents and actions,
