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Studies of human IgE synthesis are summarized and provide further insight into the cellular and molecular mechanisms involved in IgE regulation, as well as in the alterations responsible for IgE disregulation in some pathological conditions. These include the demonstration that IL-4 is the essential factor for the induction of human IgE syntheses. Another T cell-derived lymphokine, IFN-gamma negatively regulated the IgE synthesis induced by IL-4. These two lymphokines can be produced by different T helper cells, as shown in mice, but they can also be the product of the same T cells clones. Additional cellular and/or molecular signals appear to be involved in the IL-4-induced IgE synthesis, but their precise role in this process is undetermined. Finally, alternations of one or more of these regulatory mechanisms can be detected in patients with pathological conditions characterized by hyperproduction of IgE. In particular, the increased prevalence of T cells clones able to produce IL-4 appears to be a distinctive feature of patients with common atopy whereas a reduction in the proportion of IFN-gamma-producing T cells seems to be peculiar of both patients with hyper-IgE syndrome and patients with AIDS.
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
January 1999,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
January 1995,
International archives of allergy and immunology,
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
October 1996,
Annals of the New York Academy of Sciences,
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
January 1989,
International reviews of immunology,
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
July 1985,
The Journal of investigative dermatology,
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
January 1991,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
September 1990,
Immunology today,
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
June 1997,
Journal of molecular medicine (Berlin, Germany),
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
January 1988,
La Ricerca in clinica e in laboratorio,
S Romagnani, and
G Del Prete, and
E Maggi, and
P Parronchi, and
A Tiri, and
D Macchia, and
M G Giudizi, and
F Almerigogna, and
M Ricci
January 1978,
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