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The authors studied the H ferritin restriction polymorphism in 83 hemochromatosis patients and 84 controls as well as in 19 nuclear families. No significant difference was found with the ten restriction enzymes used (HindIII, EcoRI, EcoRV, PvuII, BamHI, PstI, Bg/I, Bg/II, HincII, and TaqI). Hence, the genomic abnormality responsible for idiopathic hemochromatosis is not a major deletion of an H ferritin gene. A higher frequency of one HindIII fragment, although nonsignificant when the number of comparisons made is taken into account, was observed in the patients. This HindIII fragment hybridizes with the H ferritin probe and with a 28 S ribosomal probe, and its segregation with HLA haplotypes (hence its assignment to chromosome 6) is uncertain. Its possible meaning in the expression of the disease is discussed.
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
April 1962,
Revue francaise d'etudes cliniques et biologiques,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
July 1982,
The Journal of laboratory and clinical medicine,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
June 1997,
Molecular and cellular probes,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
June 1989,
Gastroenterology,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
January 1981,
Haematologia,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
August 1982,
Clinical chemistry,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
November 1980,
Gastroenterology,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
October 1986,
Human genetics,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
January 1987,
La Ricerca in clinica e in laboratorio,
V David, and
P Papadopoulos, and
J Yaouanq, and
M Blayau, and
L Abel, and
E Zappone, and
M Perichon, and
J Drysdale, and
J Y Le Gall, and
M Simon
January 1979,
Clinical and investigative medicine. Medecine clinique et experimentale,
