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A variety of ion channels has been discovered in lymphocytes. RT-PCR and real-time PCR analysis revealed that ALL (acute lymphocytic leukemia) cell lines and human peripheral blood mononuclear cells mainly expressed TTX (tetrodotoxin)-sensitive voltage-gated sodium channels (VGSCs). Expression of VGSC protein was confirmed by western blots and Immunofluorescence. Whole-cell patch-clamp recordings showed that a sub-population (20%) of MOLT-4 cells expressed functional VGSCs, which were TTX-sensitive. Importantly, 2 μM TTX decreased the invasion of Jurkat and MOLT-4 cells ∼90%. These results indicate that the activity of VGSCs could represent a novel mechanism potentiating the invasive capacity of these cells.
Weifeng Huang, and
Chunjing Lu, and
Yong Wu, and
Shou Ouyang, and
Yuanzhong Chen
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Reproductive biology and endocrinology : RB&E,
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Yong Wu, and
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Current opinion in pharmacology,
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Yong Wu, and
Shou Ouyang, and
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Current opinion in pharmacology,
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Yong Wu, and
Shou Ouyang, and
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The Journal of biological chemistry,
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Biology of reproduction,
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Neuroreport,
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Annual review of pharmacology and toxicology,
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Current drug targets. CNS and neurological disorders,
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Epilepsia,
Weifeng Huang, and
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Shou Ouyang, and
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January 2022,
Frontiers in pharmacology,
