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The effects of various adrenergic agonists and antagonists on the diuretic/natriuretic effects of rANP (103-125) were investigated in conscious and anaesthetized normotensive rats. Pharmacological sympathetic inhibition by reserpine completely inhibited the diuretic/natriuretic effects of ANP. However, surgical renal nerve denervation did not influence the renal response to ANP. Further studies using various pharmacological agents which interfere with adrenergic activity revealed that the diuretic mechanism of action differed between conscious and anaesthetized animals. In the anaesthetized group only, dopamine (D1) blockade reduced ANP-induced diuresis. In the conscious as well as anaesthetized rats, however, pre-synaptic dopamine (D2) stimulation and alpha 2-adrenergic receptor blockade effectively inhibited the renal response to ANP. The results of this study are compatible with the notion that ANP acts indirectly within the kidney via interaction with dopamine-containing neuronal or non-neuronal structures in the kidney.
A Pettersson, and
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June 1986,
Cardiologia (Rome, Italy),
A Pettersson, and
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T Hedner
January 1989,
Polskie Archiwum Medycyny Wewnetrznej,
A Pettersson, and
J Hedner, and
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July 1997,
The journals of gerontology. Series A, Biological sciences and medical sciences,
A Pettersson, and
J Hedner, and
T Hedner
June 1988,
FEBS letters,
A Pettersson, and
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November 1992,
Zhonghua nei ke za zhi,
A Pettersson, and
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January 1990,
Medicinal research reviews,
A Pettersson, and
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November 1989,
The Journal of laboratory and clinical medicine,
A Pettersson, and
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January 1994,
Clinical and experimental pharmacology & physiology,
A Pettersson, and
J Hedner, and
T Hedner
January 1991,
Anatomy and embryology,
A Pettersson, and
J Hedner, and
T Hedner
October 1991,
Canadian journal of physiology and pharmacology,
