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Novel reassortant highly pathogenic H5N6 avian influenza viruses in poultry in China. 2015
Haibo Wu, and
Rufeng Lu, and
Xiaorong Peng, and
Lihua Xu, and
Linfang Cheng, and
Xiangyun Lu, and
Changzhong Jin, and
Tiansheng Xie, and
Hangping Yao, and
Nanping Wu
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
We characterized two novel highly pathogenic H5N6 influenza viruses isolated from Chinese poultry in 2013. Genomic analysis showed that both isolates were reassortants, and derived their genes from H5 and H6 subtype viruses found in poultry in China. The virulence of the two isolates was examined in chickens and mice, and both isolates were found to be highly pathogenic in chickens and only moderately virulent for mice. Our results show that continued circulation of these viruses could endanger both avian species and humans.
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