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CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. 2015
Suefen Kwa, and
Shanmugalakshmi Sadagopal, and
Xiaoying Shen, and
Jung Joo Hong, and
Sailaja Gangadhara, and
Rahul Basu, and
Blandine Victor, and
Smita S Iyer, and
Celia C LaBranche, and
David C Montefiori, and
Georgia D Tomaras, and
Francois Villinger, and
Bernard Moss, and
Pamela A Kozlowski, and
Rama Rao Amara
Emory Vaccine Center, Department of Microbiology and Immunology, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses of serum IgG antibodies to linear peptides of SIV Env revealed a strong response to V2, with targeting of fewer epitopes in the immunodominant region of gp41 (gp41-ID) and the V1 region as a correlate for enhanced protection. Greater expansion of antiviral CD8 T cells in the gut correlated with long-term viral control.
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