Biomaterial Database

Impact of highly concentrated contaminants on the quality of oxygen 93 % produced by pressure swing adsorption. 2014

K Züchner, and U B Pflaum, and I Meineke

Medical Engineering, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany, kzuechn@gwdg.de.

A zeolite based pressure swing adsorption (PSA) module designed to produce medicinal oxygen with 90 - 96 % oxygen content was exposed to high input concentrations and high total amounts of CO (17.7 %, 44 mol), CO2 (16.5 %, 23 mol), NO2 (0.98 %, 2 mol), NO (6.2 %, 6 mol) and SO2 (4.2 %, 6 mol). In addition the system was operated with up to 35 % argon in the feed gas. An empirical model was developed to describe the dependence of the oxygen concentration in the product on the oxygen concentration in the input. If the oxygen concentration in the feed gas was reduced below 18 % by dilution, the oxygen concentration in the product fell under the 90 % threshold. Additional effects were observed with NO, NO2 and SO2 which are apparently due to chemical reactions on the adsorbent. These effects consisted of a further decrease in the oxygen concentration measured in the product and could not be reversed by excessive regeneration of the module with air. Under the experimental conditions used, only CO was detected in the product. Appropriate CO monitoring of the input gas is considered a possible remedy for PSA modules in order to ascertain the pharmaceutical quality of the oxygen produced.

UI	MeSH Term	Description	Entries
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D010102	Oxygen Inhalation Therapy	Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)	Inhalation Therapy, Oxygen,Therapy, Oxygen Inhalation,Inhalation Therapies, Oxygen,Oxygen Inhalation Therapies,Therapies, Oxygen Inhalation
D010313	Partial Pressure	The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Partial Pressures,Pressure, Partial,Pressures, Partial
D011786	Quality Control	A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)	Control, Quality,Controls, Quality,Quality Controls
D004340	Drug Contamination	The presence of organisms, or any foreign material that makes a drug preparation impure.	Drug Adulteration,Drug Contamination, Chemical,Drug Contamination, Microbial,Drug Contamination, Physical,Drug Impurity,Adulteration, Drug,Chemical Drug Contamination,Chemical Drug Contaminations,Contamination, Chemical Drug,Contamination, Drug,Contamination, Microbial Drug,Contamination, Physical Drug,Contaminations, Chemical Drug,Contaminations, Microbial Drug,Contaminations, Physical Drug,Drug Adulterations,Drug Contaminations,Drug Contaminations, Chemical,Drug Contaminations, Microbial,Drug Contaminations, Physical,Drug Impurities,Impurity, Drug,Microbial Drug Contamination,Microbial Drug Contaminations,Physical Drug Contamination,Physical Drug Contaminations
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000327	Adsorption	The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.	Adsorptions