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Biosynthesis of human diazepam and clonazepam metabolites. 2015
Núbia C de Paula, and
Kelly C F Araujo Cordeiro, and
Paula L de Melo Souza, and
Diogo F Nogueira, and
Diego B da Silva e Sousa, and
Maísa B Costa, and
François Noël, and
Valéria de Oliveira
Laboratório de Bioconversão, Faculdade de Farmácia-Universidade Federal de Goiás, Rua 240 esquina com 5(ª) Avenida S/N., Praça Universitária, CP 131, Setor Universitário, CEP: 74.605-220 Goiânia, GO, Brazil; Laboratório de Saúde Pública Dr. Giovanni Cysneiros, Secretaria Estadual do Estado de Goiás, Goiânia, GO, Brazil.
A screening of fungal and microbial strains allowed to select the best microorganisms to produce in high yields some of the human metabolites of two benzodiazepine drugs, diazepam and clonazepam, in order to study new pharmacological activities and for chemical standard proposes. Among the microorganisms tested, Cunninghamella echinulata ATCC 9244 and Rhizopus arrhizus ATCC 11145 strains, were the most active producers of the mains metabolites of diazepam which included demethylated, hydroxylated derivatives. Beauveria bassiana ATCC 7159 and Chaetomium indicum LCP 984200 produced the 7 amino-clonazepam metabolite and a product of acid hydrolysis of this benzodiazepine.
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