Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves' disease and Hashimoto's thyroiditis. 1989

M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.

HLA antigen phenotypes and BglII restriction fragment length polymorphism of T cell receptor beta-chain (TCR beta) gene were analyzed in 61 patients with Graves' disease and 50 patients with Hashimoto's thyroiditis. The antigen frequency of HLA-Bw46 in both Graves' disease (23.0%) and Hashimoto's thyroiditis (24.0%) was significantly higher than that in normal population (8.0%), with relative risks (RR) of 3.45 [corrected P (Pc) less than 0.009] and 3.66 (Pc less than 0.02), respectively. Significantly increased frequency of HLA-B51 antigen was also found in Hashimoto's thyroiditis (40.0% vs. 16.3% in controls; RR, 3.42; Pc less than 0.002). Hybridization of BglII-digested DNA with TCR beta probe revealed two alleles of 9.3 and 8.6 kilobases. The allele frequency of 8.6 kilobases in Graves' disease (79%) and Hashimoto's thyroiditis (76%) was significantly higher (P less than 0.01 and P less than 0.05, respectively) than that in controls (64%). The frequency of homozygous state 8.6/8.6 was significantly increased in both Graves' disease (62%) and Hashimoto's thyroiditis (60%) over that in controls (39%); the RR of 8.6/8.6 in Graves' disease and Hashimoto's thyroiditis were 2.55 (P less than 0.01) and 2.31 (P less than 0.05), respectively. These results indicate that in Japanese subjects at least two loci are involved in the susceptibility to Graves' disease and Hashimoto's thyroiditis, one related to HLA and another to TCR beta.

UI MeSH Term Description Entries
D007564 Japan A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo. Bonin Islands
D008297 Male Males
D009693 Nucleic Acid Hybridization Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503) Genomic Hybridization,Acid Hybridization, Nucleic,Acid Hybridizations, Nucleic,Genomic Hybridizations,Hybridization, Genomic,Hybridization, Nucleic Acid,Hybridizations, Genomic,Hybridizations, Nucleic Acid,Nucleic Acid Hybridizations
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D011948 Receptors, Antigen, T-Cell Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains. Antigen Receptors, T-Cell,T-Cell Receptors,Receptors, T-Cell Antigen,T-Cell Antigen Receptor,T-Cell Receptor,Antigen Receptor, T-Cell,Antigen Receptors, T Cell,Receptor, T-Cell,Receptor, T-Cell Antigen,Receptors, T Cell Antigen,Receptors, T-Cell,T Cell Antigen Receptor,T Cell Receptor,T Cell Receptors,T-Cell Antigen Receptors
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D005260 Female Females
D005796 Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes

Related Publications

M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
June 1996, Veterinary immunology and immunopathology,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
April 1990, Arthritis and rheumatism,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
January 1995, Autoimmunity,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
January 1991, Animal genetics,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
July 1988, The Journal of rheumatology,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
October 1988, Acta endocrinologica,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
February 1987, Arthritis and rheumatism,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
October 1987, The Journal of clinical endocrinology and metabolism,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
September 1985, The Journal of experimental medicine,
M Ito, and M Tanimoto, and H Kamura, and M Yoneda, and Y Morishima, and K Yamauchi, and T Itatsu, and K Takatsuki, and H Saito
September 1985, The Journal of clinical investigation,
Copied contents to your clipboard!