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In the present study, using chalcone as a lead compound, a series of its derivatives (compounds 1-30) were designed and synthesised. Their activity of anti-pathogenic fungi of plants has been evaluated. It is found that these compounds have good antifungal activity against Sclerotinia sclerotiorum, Helminthosprium maydis, Botrytis cinerea, Rhizoctonia solani and Gibberella zeae. Among them, the inhibition of growth for compound 30 against S. sclerotiorum showed 89.9%, with the median effective concentrations (EC50) of 15.4 μg mL(-1). The inhibition of growth for compounds 28, 29 and 30 at a concentration of 100 μg mL(-1) against H. maydis is 90.3%, 90.7% and 91.1%, with EC50 of 15.1, 18.3 and 18.1μg mL(-1), respectively.
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
January 2015,
Journal of advanced pharmaceutical technology & research,
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
May 2024,
Chemistry & biodiversity,
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
February 2022,
Journal of agricultural and food chemistry,
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
April 2013,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
May 1998,
Bioorganic & medicinal chemistry letters,
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
April 2005,
Farmaco (Societa chimica italiana : 1989),
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
September 2010,
Molecules (Basel, Switzerland),
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
June 2023,
Chemistry & biodiversity,
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
April 2024,
Molecular diversity,
Yuanyuan Zheng, and
Xuesong Wang, and
Sumei Gao, and
Min Ma, and
Guiming Ren, and
Huabing Liu, and
Xiaohong Chen
January 2017,
Porto biomedical journal,
