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The hypothesis that in hypoglycaemia adrenoceptor-blocking drugs may enhance those metabolic effects of the catecholamines that remain unblocked has been investigated in 12 volunteers. alpha-Adrenoceptor blockade with urapidil increased the heart rate and the plasma noradrenaline level, and increased the beta-adrenoceptor mediated cellular uptake of potassium and phosphate, and the production of lactate. Posthypoglycaemic glucose intolerance and the counterregulatory responses of hGH and cortisol remained unchanged. Plasma adrenaline, the alpha-adrenoceptor mediated responses of cortisol and hGH, and the diastolic blood pressure were increased by propranolol. Adrenoceptor blocking drugs produce an indirect stimulatory effect by eliciting a reflex increase in sympathetic tone, which is manifested as stimulation of receptors of the type that has not been blocked.
K G Petersen, and
P Katschker, and
L Kerp
June 1984,
Masui. The Japanese journal of anesthesiology,
K G Petersen, and
P Katschker, and
L Kerp
December 1966,
Lancet (London, England),
K G Petersen, and
P Katschker, and
L Kerp
May 1975,
Lancet (London, England),
K G Petersen, and
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L Kerp
September 1982,
Clinical science (London, England : 1979),
K G Petersen, and
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L Kerp
September 1976,
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K G Petersen, and
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L Kerp
March 1986,
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K G Petersen, and
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L Kerp
April 1968,
Lancet (London, England),
K G Petersen, and
P Katschker, and
L Kerp
January 1967,
Lancet (London, England),
K G Petersen, and
P Katschker, and
L Kerp
March 1967,
Lancet (London, England),
K G Petersen, and
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January 1990,
Therapie,
