Increased resveratrol production in wines using engineered wine strains Saccharomyces cerevisiae EC1118 and relaxed antibiotic or auxotrophic selection. 2015

Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
Dept. of Bioengineering, College of Food Science, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510640, China.

Resveratrol is a polyphenolic compound with diverse beneficial effects on human health. Red wine is the major dietary source of resveratrol but the amount that people can obtain from wines is limited. To increase the resveratrol production in wines, two expression vectors carrying 4-coumarate: coenzyme A ligase gene (4CL) from Arabidopsis thaliana and resveratrol synthase gene (RS) from Vitis vinifera were transformed into industrial wine strain Saccharomyces cerevisiae EC1118. When cultured with 1 mM p-coumaric acid, the engineered strains grown with and without the addition of antibiotics produced 8.249 and 3.317 mg/L of trans-resveratrol in the culture broth, respectively. Resveratrol content of the wine fermented with engineered strains was twice higher than that of the control, indicating that our engineered strains could increase the production of resveratrol during wine fermentation.

UI MeSH Term Description Entries
D011422 Propionates Derivatives of propionic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxyethane structure. Propanoate,Propanoic Acid,Propionate,Propanoates,Propanoic Acid Derivatives,Propanoic Acids,Propionic Acid Derivatives,Propionic Acids,Acid, Propanoic,Acids, Propanoic,Acids, Propionic,Derivatives, Propanoic Acid,Derivatives, Propionic Acid
D003066 Coenzyme A Ligases Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1. Acyl CoA Synthetase,Acyl CoA Synthetases,Acyl Coenzyme A Synthetase,Acyl Coenzyme A Synthetases,Coenzyme A Ligase,Coenzyme A Synthetase,Coenzyme A Synthetases,Acid-Thiol Ligases,Co A Ligases,A Ligase, Coenzyme,A Synthetase, Coenzyme,Acid Thiol Ligases,CoA Synthetase, Acyl,CoA Synthetases, Acyl,Ligase, Coenzyme A,Ligases, Acid-Thiol,Ligases, Co A,Ligases, Coenzyme A,Synthetase, Acyl CoA,Synthetase, Coenzyme A,Synthetases, Acyl CoA,Synthetases, Coenzyme A
D003373 Coumaric Acids Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants. Coumaric Acid,Hydroxycinnamic Acid,Hydroxycinnamic Acids,Acid, Coumaric,Acid, Hydroxycinnamic,Acids, Coumaric,Acids, Hydroxycinnamic
D005285 Fermentation Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID. Fermentations
D005818 Genetic Engineering Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc. Genetic Intervention,Engineering, Genetic,Intervention, Genetic,Genetic Interventions,Interventions, Genetic
D000077185 Resveratrol A stilbene and non-flavonoid polyphenol produced by various plants including grapes and blueberries. It has anti-oxidant, anti-inflammatory, cardioprotective, anti-mutagenic, and anti-carcinogenic properties. It also inhibits platelet aggregation and the activity of several DNA HELICASES in vitro. 3,4',5-Stilbenetriol,3,4',5-Trihydroxystilbene,3,5,4'-Trihydroxystilbene,Resveratrol, (Z)-,Resveratrol-3-sulfate,SRT 501,SRT-501,SRT501,cis-Resveratrol,trans-Resveratrol,trans-Resveratrol-3-O-sulfate,Resveratrol 3 sulfate,cis Resveratrol,trans Resveratrol,trans Resveratrol 3 O sulfate
D000217 Acyltransferases Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3. Acyltransferase
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D012441 Saccharomyces cerevisiae A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement. Baker's Yeast,Brewer's Yeast,Candida robusta,S. cerevisiae,Saccharomyces capensis,Saccharomyces italicus,Saccharomyces oviformis,Saccharomyces uvarum var. melibiosus,Yeast, Baker's,Yeast, Brewer's,Baker Yeast,S cerevisiae,Baker's Yeasts,Yeast, Baker
D013267 Stilbenes Organic compounds that contain 1,2-diphenylethylene as a functional group. Stilbene,Stilbene Derivative,Stilbene Derivatives,Stilbenoid,Stilbenoids,Derivative, Stilbene,Derivatives, Stilbene

Related Publications

Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
June 1976, Mutation research,
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
September 2012, Enzyme and microbial technology,
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
November 2015, Metabolic engineering,
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
July 2018, Food research international (Ottawa, Ont.),
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
June 2013, Journal of food science,
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
May 2011, Metabolic engineering,
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
August 2021, ACS synthetic biology,
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
May 2015, Current microbiology,
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
February 2024, Biotechnology letters,
Ping Sun, and Jing-Long Liang, and Lin-Zhi Kang, and Xiao-Yan Huang, and Jia-Jun Huang, and Zhi-Wei Ye, and Li-Qiong Guo, and Jun-Fang Lin
August 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Copied contents to your clipboard!