Reversal of leukotriene D4- and leukotriene E4-induced airway constriction in the guinea pig. 1989

S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
Department of Immunology, Pulmonary and Leukotriene Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.

Conscious Hartley guinea pigs were challenged with LTD4 or LTE4 aerosols. When dynamic compliance (Cdyn) decreased to 50% of its baseline value, the challenge aerosols were stopped and treatment aerosols of salbutamol, the LTD4/E4 antagonist LY171883 Na, atropine, or sodium chloride (control) were begun. After 5 min of continuous exposure to the treatment aerosol, each animal was killed and excised lung gas volume (ELGV) was measured. Salbutamol was equally effective in reversing LTD4- and LTE4-induced Cdyn changes. Aerosolized LY171883 Na was effective against both agonists, but was about threefold more potent against LTE4. In contrast, atropine was very effective in reversing LTD4-induced Cdyn changes, but produced minimal reversal when LTE4 was the challenge agent. Pulmonary gas trapping results supported these observations; ELGV values were closely correlated with 5-min Cdyn measurements for both LTD4 (r = -0.817) and LTE4 (r = -0.831). Thus, although LTD4 and LTE4 are though to act on the same or similar receptors, the pattern of pharmacologic reversal at comparable levels of airway obstruction differs for these two agonists.

UI MeSH Term Description Entries
D008170 Lung Compliance The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562) Compliance, Lung,Compliances, Lung,Lung Compliances
D008176 Lung Volume Measurements Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle. Lung Capacities,Lung Volumes,Capacity, Lung,Lung Capacity,Lung Volume,Lung Volume Measurement,Measurement, Lung Volume,Volume, Lung
D008297 Male Males
D012119 Respiration The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration ( Breathing
D001980 Bronchi The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI. Primary Bronchi,Primary Bronchus,Secondary Bronchi,Secondary Bronchus,Tertiary Bronchi,Tertiary Bronchus,Bronchi, Primary,Bronchi, Secondary,Bronchi, Tertiary,Bronchus,Bronchus, Primary,Bronchus, Secondary,Bronchus, Tertiary
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000098 Acetophenones Derivatives of the simplest aromatic ketone acetophenone (of general formula C6H5C(O)CH3).
D000403 Airway Resistance Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow. Airway Resistances,Resistance, Airway,Resistances, Airway
D000420 Albuterol A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol. Salbutamol,2-t-Butylamino-1-(4-hydroxy-3-hydroxy-3-hydroxymethyl)phenylethanol,Albuterol Sulfate,Proventil,Sultanol,Ventolin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
May 1983, The American journal of cardiology,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
November 1995, Acta anaesthesiologica Scandinavica,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
June 1995, Prostaglandins, leukotrienes, and essential fatty acids,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
September 1989, British journal of pharmacology,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
October 1998, European journal of pharmacology,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
November 1999, Nihon rinsho. Japanese journal of clinical medicine,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
July 2010, Nihon rinsho. Japanese journal of clinical medicine,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
August 2005, Nihon rinsho. Japanese journal of clinical medicine,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
August 1984, Proceedings of the National Academy of Sciences of the United States of America,
S A Silbaugh, and P W Stengel, and P A Pechous, and W S Marshall
January 1985, Progress in clinical and biological research,
Copied contents to your clipboard!