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Some semen characteristics of eight male patients with clinically inactive ulcerative colitis were investigated. Semen analysis was carried out twice during salicylazosulfapyridine (SASP) treatment and repeated twice after at least 3 months' treatment with mesalazine. The motility variables all showed significant improvement during mesalazine treatment: the graded motility (p less than 0.05), motility in percentage (p less than 0.01), and the penetration in egg white (p less than 0.05). The semen plasma was analyzed for mesalazine and the metabolite Ac-mesalazine during both regimens. There was no difference in the semen plasma concentration of mesalazine during the two regimens, whereas Ac-mesalazine was significantly higher during mesalazine treatment than during SASP treatment, indicating that other SASP metabolites, most likely sulfapyridine, are the agent causing the abnormal sperm characteristics. We suggest that pure mesalazine preparations are a safer alternative in young men with chronic inflammatory bowel disease.
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
August 1987,
Gut,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
May 1953,
La Riforma medica,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
December 1995,
Gut,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
January 1989,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
July 1949,
The Medical clinics of North America,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
March 2006,
International journal of colorectal disease,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
January 2016,
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
November 2017,
Echo research and practice,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
May 1952,
Gastroenterology,
N Kjaergaard, and
L A Christensen, and
J G Lauritsen, and
S N Rasmussen, and
S H Hansen
January 1953,
Journal of the American Medical Association,
