Development of a cerebrospinal fluid lateral reservoir model in rhesus monkeys (Macaca mulatta). 2015

Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
National Cancer Institute, Bethesda Maryland, USA. mccullyc@mail.nih.gov.

Rapid, serial, and humane collection of cerebrospinal fluid (CSF) in nonhuman primates (NHP) is an essential element of numerous research studies and is currently accomplished via two different models. The CSF reservoir model (FR) combines a catheter in the 4th ventricle with a flexible silastic reservoir to permit circulating CSF flow. The CSF lateral port model (LP) consists of a lateral ventricular catheter and an IV port that provides static access to CSF and volume restrictions on sample collection. The FR model is associated with an intensive, prolonged recovery and frequent postsurgical hydrocephalus and nonpatency, whereas the LP model is associated with an easier recovery. To maximize the advantages of both systems, we developed the CSF lateral reservoir model (LR), which combines the beneficial features of the 2 previous models but avoids their limitations by using a reservoir for circulating CSF flow combined with catheter placement in the lateral ventricle. Nine adult male rhesus monkeys were utilized in this study. Pre-surgical MRI was performed to determine the coordinates of the lateral ventricle and location of choroid plexus (CP). The coordinates were determined to avoid the CP and major blood vessels. The predetermined coordinates were 100% accurate, according to MRI validation. The LR system functioned successfully in 67% of cases for 221 d, and 44% remain functional at 426 to 510 d postoperatively. Compared with established models, our LR model markedly reduced postoperative complications and recovery time. Development of the LR model was successful in rhesus macaques and is a useful alternative to the FR and LP methods of CSF collection from nonhuman primates.

UI MeSH Term Description Entries
D008253 Macaca mulatta A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans. Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D002404 Catheterization Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions. Cannulation,Cannulations,Catheterizations
D002555 Cerebrospinal Fluid A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES. Cerebro Spinal Fluid,Cerebro Spinal Fluids,Cerebrospinal Fluids,Fluid, Cerebro Spinal,Fluid, Cerebrospinal,Fluids, Cerebro Spinal,Fluids, Cerebrospinal,Spinal Fluid, Cerebro,Spinal Fluids, Cerebro
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013048 Specimen Handling Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation. Specimen Collection,Collection, Specimen,Collections, Specimen,Handling, Specimen,Handlings, Specimen,Specimen Collections,Specimen Handlings
D020547 Lateral Ventricles Cavity in each of the CEREBRAL HEMISPHERES derived from the cavity of the embryonic NEURAL TUBE. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle. Subventricular Zone,Lateral Ventricle,Subventricular Zones,Ventricle, Lateral,Ventricles, Lateral,Zone, Subventricular,Zones, Subventricular
D023421 Models, Animal Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing. Experimental Animal Models,Laboratory Animal Models,Animal Model,Animal Model, Experimental,Animal Model, Laboratory,Animal Models,Animal Models, Experimental,Animal Models, Laboratory,Experimental Animal Model,Laboratory Animal Model,Model, Animal,Model, Experimental Animal,Model, Laboratory Animal,Models, Experimental Animal,Models, Laboratory Animal

Related Publications

Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
March 1999, AIDS research and human retroviruses,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
May 2007, Vision research,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
February 1970, The British veterinary journal,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
July 2008, Animal cognition,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
February 1974, Fertility and sterility,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
May 2011, Animal cognition,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
January 1969, Folia primatologica; international journal of primatology,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
January 1984, Veterinary pathology,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
July 1994, Journal of medical primatology,
Cynthia M Lester McCully, and John Bacher, and Rhonda P MacAllister, and Emilie A Steffen-Smith, and Kadharbatcha Saleem, and Marvin L Thomas, and Rafael Cruz, and Katherine E Warren
November 2016, Developmental science,
Copied contents to your clipboard!