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We have constructed a genetic linkage map of human chromosome 10 based on DNA probes that detect 47 restriction fragment length polymorphisms (RFLPs) at 32 different loci. Segregation data were collected on a set of multigenerational families provided by the Centre d'Etude du Polymorphisme Humain and maps were constructed using recently developed multipoint analysis techniques. The length of the sex-averaged map is 178 cM and the sex-specific map lengths are 131 cM in males and 255 cM in females. Recombination is significantly higher in female meioses. The mean distance between loci is 5.6 cM for the sex-averaged map. The genetic map spans the length of the chromosome as judged by physical localization of probes by in situ hybridization techniques and mapping of the probes on human-hamster hybrid cell lines containing all or part of chromosome 10. The informativeness of two loci near the locus responsible for multiple endocrine neoplasia type 2A (MEN-2A) has been increased by isolation of cosmids that reveal additional RFLPs at these loci.
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
May 1993,
Genomics,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
May 1991,
Genomics,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
July 2002,
Yi chuan xue bao = Acta genetica Sinica,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
November 1992,
Genomics,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
June 1992,
Genomics,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
November 1988,
Genomics,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
February 1992,
Genomics,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
November 1992,
Genomics,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
August 1988,
Genomics,
D W Bowden, and
T C Gravius, and
P Green, and
K Falls, and
D Wurster-Hill, and
W Noll, and
H Müller-Kahle, and
H Donis-Keller
January 1993,
Genomics,
