BIOMAT Database Logo BIOMAT Database Logo

Disposition of 5-aminosalicylic acid from 5-aminosalicylic acid-delivering drugs during accelerated intestinal transit in healthy volunteers. 1989

M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
Dept. of Gastrointestinal and Liver Diseases, University Hospital Nijmegen, The Netherlands.

In eight healthy volunteers accelerated intestinal transit time was induced with bisacodyl, and urinary and faecal excretion of sulphasalazine, olsalazine, 5-aminosalicylic acid (5-ASA), and acetyl-5-ASA was studied after a single oral dose of 3.3 mmol sulphasalazine, olsalazine, Pentasa, and Salofalk and 2.6 mmol of Asacol. The faecal and urinary excretion of acetyl-5-ASA was lowest after intake of sulphasalazine and olsalazine and highest after intake of Pentasa and Salofalk. The figures for Asacol were intermediate. This indicates insufficient release of 5-ASA from sulphasalazine and olsalazine. When the results of this study are compared with those of a previous study without accelerated transit time, the disposition of 5-ASA from all the 5-ASA-delivering drugs is influenced unfavourably by an accelerated gut transit but most pronounced in the case of sulphasalazine, olsalazine, and Asacol. The impaired release from the azo compounds sulphasalazine and olsalazine is a result of far less complete splitting of the diazo bond.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001726 Bisacodyl A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871) Agaroletten,Apo-Bisacodyl,Bekunis Bisacodyl,Bicol,Bisac-Evac,Bisacodyl Tannex,Bisacodyl Uniserts,Bisalax,Bisco-Lax,Bisco-Zitron,Dulco-Lax,Dulco-lax perles,Dulcolax,Durolax,Fleet Bisacodyl,Florisan N,Laxagetten,Laxanin,Laxans-ratiopharm,Laxbene,Laxysat Bürger,Lünolax,Rytmil,Ulcolax,ratio-Bisacodyl,Apo Bisacodyl,Bisac Evac,Bisacodyl, Bekunis,Bisacodyl, Fleet,Bisco Lax,Bisco Zitron,Dulco Lax,Dulco lax perles,Dulcolax perles,Laxans ratiopharm,Tannex, Bisacodyl,Uniserts, Bisacodyl,ratio Bisacodyl
D005260 Female Females
D005772 Gastrointestinal Transit Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function. GI Transit,GI Transits,Gastrointestinal Transits,Transit, GI,Transit, Gastrointestinal,Transits, GI,Transits, Gastrointestinal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000636 Aminosalicylic Acids A group of 2-hydroxybenzoic acids that can be substituted by amino groups at any of the 3-, 4-, 5-, or 6-positions. Acids, Aminosalicylic
D012460 Sulfasalazine A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907) Salicylazosulfapyridine,Asulfidine,Azulfadine,Azulfidine,Azulfidine EN,Colo-Pleon,Pleon,Pyralin EN,Salazopyrin,Salazosulfapyridine,Sulfasalazin medac,Sulfasalazin-Heyl,Sulfasalazine FNA,Sulphasalazine,Ucine,Ulcol,ratio-Sulfasalazine,Colo Pleon,Sulfasalazin Heyl,ratio Sulfasalazine
D019804 Mesalamine An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed) 5-Aminosalicylate,Mesalazine,5-Aminosalicylic Acid,Asacol,Asacolon,Ascolitin,Canasa,Claversal,Fivasa,Lixacol,Mesalamine Hydrochloride,Mesalamine Monosodium Salt,Mesasal,Novo-5 ASA,Pentasa,Rowasa,Salofalk,m-Aminosalicylic Acid,meta-Aminosalicylic Acid,5 Aminosalicylate,5 Aminosalicylic Acid,Hydrochloride, Mesalamine,Monosodium Salt, Mesalamine,Novo 5 ASA,m Aminosalicylic Acid,meta Aminosalicylic Acid

Related Publications

M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
Release of 5-aminosalicylic acid from Pentasa during normal and accelerated intestinal transit time.
March 1987, British journal of clinical pharmacology,
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
5-aminosalicylic acid release from a new controlled-release mesalazine formulation during gastrointestinal transit in healthy volunteers.
January 2006, Alimentary pharmacology & therapeutics,
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
Gastrointestinal transit and release of 5-aminosalicylic acid from 153Sm-labelled mesalazine pellets vs. tablets in male healthy volunteers.
May 2003, Alimentary pharmacology & therapeutics,
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
Oroileal transit of 5-aminosalicylic acid.
February 1994, Gut,
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
Disposition of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid in fetal and maternal body fluids during treatment with different 5-aminosalicylic acid preparations.
May 1994, Acta obstetricia et gynecologica Scandinavica,
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
Oroileal transit of slow release 5-aminosalicylic acid.
May 1993, Gut,
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
A study on intestinal transit time on healthy volunteers in Assam.
January 1983, Tropical gastroenterology : official journal of the Digestive Diseases Foundation,
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
Disposition of 5-aminosalicylic acid, the active metabolite of sulphasalazine, in man.
January 1983, European journal of clinical pharmacology,
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
[Nephritis from 5-aminosalicylic acid].
February 1989, Deutsche medizinische Wochenschrift (1946),
M C Rijk, and R A van Hogezand, and A van Schaik, and J H van Tongeren
Gastrointestinal transit of an enteric-coated delayed-release 5-aminosalicylic acid tablet.
June 1987, Alimentary pharmacology & therapeutics,
Copied contents to your clipboard!