-transparent.png){kind=logo}
1. Intracellular free calcium ([Ca2+]i) was monitored by means of Fura-2 fluorescence measurements in hippocampal cells in primary cultures from newborn rats. 2. In external media containing 200 microM-DL-2-amino-5-phosphonovalerate and 1 mM-kynurenate, but no added Ca2+, an increase in [Ca2+]i was observed in 30-40% of cells examined in response to quisqualate or L-glutamate. 3. Under such conditions, [Ca2+]i often increased gradually with a latency of a few seconds after application of the agonists. 4. Pre-treatment of the cultured cells with pertussis toxin reduced the extent of quisqualate-stimulated [Ca2+]i increase in Ca2+-free media, but the percentage of the responsive cells was not affected appreciably. 5. It is concluded that quisqualate and L-glutamate can trigger the release of Ca2+ from intracellular Ca2+ stores, most likely by activating a glutamate receptor coupled to a pertussis toxin-sensitive G-protein.
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
September 1998,
The Journal of physiology,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
March 1994,
Neuroscience letters,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
February 1995,
Neuroscience letters,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
January 1995,
Life sciences,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
November 2003,
Anesthesia and analgesia,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
June 2013,
Neuroreport,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
January 1998,
Acta biochimica Polonica,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
November 1988,
Proceedings of the National Academy of Sciences of the United States of America,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
December 2018,
The European journal of neuroscience,
S Furuya, and
H Ohmori, and
T Shigemoto, and
H Sugiyama
January 1999,
Annals of the New York Academy of Sciences,
