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Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus. 2015
Liana C Chan, and
Li Basuino, and
Binh Diep, and
Stephanie Hamilton, and
Som S Chatterjee, and
Henry F Chambers
Division of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, California, USA lchan@labiomed.org.
The role of mecA mutations in conferring resistance to ceftobiprole and ceftaroline, cephalosporins with anti-methicillin-resistant Staphylococcus aureus (MRSA) activity, was determined with MRSA strains COL and SF8300. The SF8300 ceftaroline-passaged mutant carried a single mecA mutation, E447K (E-to-K change at position 447), and expressed low-level resistance. This mutation in COL conferred high-level resistance to ceftobiprole but only low-level resistance to ceftaroline. The COL ceftaroline-passaged mutant, which expressed high-level resistance to ceftobiprole and ceftaroline, had mutations in pbp2, pbp4, and gdpP but not mecA.
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