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It has been shown previously that the endogenous brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) can act as an antiopiate and can also increase binding and function at the GABAA/benzodiazepine receptor complex. We now describe the effects of this tetrapeptide in two models in which the antiopiate naloxone has been reported to decrease the activity of benzodiazepines. Unlike naloxone, Tyr-MIF-1 and MIF-1 neither prevented chlordiazepoxide-induced locomotor hyperactivity in mice on a tilting floor nor suppressed chlordiazepoxide-induced eating in rats. Thus, in these two systems, Try-MIF-1 did not act as an antiopiate or alter the effects of a benzodiazepine, indicating a selectivity in the actions of Tyr-MIF-1.
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
January 1994,
Peptides,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
January 1987,
Peptides,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
December 1987,
Pharmacology, biochemistry, and behavior,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
January 1993,
Peptides,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
January 1989,
Peptides,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
November 1988,
Research communications in chemical pathology and pharmacology,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
February 1994,
Biochemical pharmacology,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
October 1986,
Pharmacology, biochemistry, and behavior,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
December 1987,
Brain research bulletin,
A J Kastin, and
D Schwartzenburg, and
L Tsui, and
L G Miller, and
G A Olson, and
R D Olson
December 1985,
Pharmacology, biochemistry, and behavior,
