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The transglutaminase involvement in phytohaemagglutinin (PHA) stimulated lymphocyte transformation (measured as (3H)thymidine incorporation) was studied in lymphocytes from 20 patients with type 2 diabetes mellitus and 20 healthy controls by including in the system the specific transglutaminase pseudosubstrate monodansylthiacadaverine (MDTC). In the presence of MDTC, (3H)thymidine incorporation was significantly and concentration-dependently reduced in both groups but more pronouncedly in the diabetes patients. The MDTC concentration needed to give a 50% reduction of the PHA-stimulated (3H)thymidine incorporation was significantly lower in lymphocytes from diabetic patients than in those from controls (p less than 0.02). The data suggest impaired lymphocyte transglutaminase function in type 2 diabetes mellitus.
K Berntorp, and
K F Eriksson, and
E Berntorp
May 1987,
Diabetes research (Edinburgh, Scotland),
K Berntorp, and
K F Eriksson, and
E Berntorp
April 1987,
Journal of clinical & laboratory immunology,
K Berntorp, and
K F Eriksson, and
E Berntorp
January 1986,
Clinical and experimental immunology,
K Berntorp, and
K F Eriksson, and
E Berntorp
June 2018,
Biochemical and biophysical research communications,
K Berntorp, and
K F Eriksson, and
E Berntorp
March 2000,
Orvosi hetilap,
K Berntorp, and
K F Eriksson, and
E Berntorp
March 1992,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
K Berntorp, and
K F Eriksson, and
E Berntorp
October 2000,
Obesity reviews : an official journal of the International Association for the Study of Obesity,
K Berntorp, and
K F Eriksson, and
E Berntorp
September 1992,
Diabetologia,
K Berntorp, and
K F Eriksson, and
E Berntorp
May 2015,
Clinical biochemistry,
K Berntorp, and
K F Eriksson, and
E Berntorp
November 1987,
Casopis lekaru ceskych,
