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The hemodynamic parameters (right atrial pressure, mean pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac index, heart rate, blood pressure) and neurohumoral responses (alpha-ANP, plasma renin activity, aldosterone, angiotensin II) of Captopril, oral ACE inhibitor, and Bunazosin, oral alpha 1-blocker, were investigated in 28 patients with congestive heart failure at rest and after exercise. These data were analysed in both acute and chronic phases. 1) Acute effect. Captopril produced significant improvement of neurohumoral factors at rest and also after exercise. Bunazosin reduced alpha-ANP, but other neurohumoral factors did not change. Bunazosin produced significant hemodynamic improvement both at rest and after exercise. 2) Chronic effect. Captopril produced significant hemodynamic improvement both at rest and after exercise. Improvement of neurohumoral factors in acute phase was also preserved at chronic phase. On Bunazosin, improvement of hemodynamics at acute phase was also preserved at chronic phase without deterioration of neurohumoral factors.
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
May 1993,
Japanese circulation journal,
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
January 1989,
American heart journal,
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
January 1990,
Cardiology,
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
April 1985,
British heart journal,
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
May 1983,
Circulation,
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
May 1991,
The American journal of medicine,
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
June 1989,
Cardiologia (Rome, Italy),
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
December 1990,
Japanese circulation journal,
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
September 1983,
Japanese heart journal,
Y Kawahara, and
K Hasegawa, and
T Sawayama, and
S Inoue, and
T Nakamura, and
S Kakumae, and
S Tadaoka, and
M Nakao, and
S Nezuo
November 2000,
Journal of the American College of Cardiology,
