BIOMAT Database Logo BIOMAT Database Logo

Simultaneous measurement of methyl tert-butyl ether and tert-butyl alcohol in human serum by headspace solid-phase microextraction gas chromatography-mass spectrometry. 2015

Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
School of Public Health, Wuhan University of Science and Technology, Huangjiahu West Road, 430065, Wuhan, Hubei, China.

The abundant production of methyl tert-butyl ether (MTBE) and its widespread use have led to an increase in the potential for human exposure. This work described a simple, fast, sensitive, reliable and low-cost method for the simultaneous measurement of MTBE and its metabolite, tert-butyl alcohol (TBA) in human serum by headspace solid-phase microextraction gas chromatography-mass spectrometry. Extraction conditions were optimized and 40 °C, 10 min, 250 rpm and 0.3 g NaCl for a 1 mL sample were the optimal conditions. This method showed good analytical performance in terms of sensitivity with limits of detection in serum (1 mL) of 0.03 µg/L for MTBE and 0.05 µg/L for TBA, accuracy (mean recovery values) from 75.8% to 85.8%, precision (relative standard deviations) <10% and sample stability (biodegradation) <10% after 28 days. A verification experiment proved the reproducibility and stability of this method as well. Finally the method was used to detect 212 specimens, and the internal dose levels for MTBE in human serum were presented in China.

UI MeSH Term Description Entries
D008401 Gas Chromatography-Mass Spectrometry A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds. Chromatography, Gas-Liquid-Mass Spectrometry,Chromatography, Gas-Mass Spectrometry,GCMS,Spectrometry, Mass-Gas Chromatography,Spectrum Analysis, Mass-Gas Chromatography,Gas-Liquid Chromatography-Mass Spectrometry,Mass Spectrometry-Gas Chromatography,Chromatography, Gas Liquid Mass Spectrometry,Chromatography, Gas Mass Spectrometry,Chromatography, Mass Spectrometry-Gas,Chromatography-Mass Spectrometry, Gas,Chromatography-Mass Spectrometry, Gas-Liquid,Gas Chromatography Mass Spectrometry,Gas Liquid Chromatography Mass Spectrometry,Mass Spectrometry Gas Chromatography,Spectrometries, Mass-Gas Chromatography,Spectrometry, Gas Chromatography-Mass,Spectrometry, Gas-Liquid Chromatography-Mass,Spectrometry, Mass Gas Chromatography,Spectrometry-Gas Chromatography, Mass,Spectrum Analysis, Mass Gas Chromatography
D008738 Methyl Ethers A group of compounds that contain the general formula R-OCH3. Ethers, Methyl
D001800 Blood Specimen Collection The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc. Blood Specimen Collections,Collection, Blood Specimen,Collections, Blood Specimen,Specimen Collection, Blood,Specimen Collections, Blood
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D013696 Temperature The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms. Temperatures
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D016273 Occupational Exposure The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation. Exposure, Occupational,Exposures, Occupational,Occupational Exposures

Related Publications

Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Reevaluation of headspace solid-phase microextraction and gas chromatography-mass spectrometry for the determination of methyl tert-butyl ether in water samples.
December 2003, Journal of chromatography. A,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Determination of metaldehyde in human serum by headspace solid-phase microextraction and gas chromatography-mass spectrometry.
November 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Measurement of methyl tert-butyl ether and tert-butyl alcohol in human blood by purge-and-trap gas chromatography-mass spectrometry using an isotope-dilution method.
January 1995, Journal of analytical toxicology,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Determination of methyl tert-butyl ether and tert-butyl alcohol in human urine by high-temperature purge-and-trap gas chromatography-mass spectrometry.
January 1998, Journal of analytical toxicology,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Determination of low level methyl tert-butyl ether, ethyl tert-butyl ether and methyl tert-amyl ether in human urine by HS-SPME gas chromatography/mass spectrometry.
January 2007, Analytica chimica acta,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
A rapid and sensitive method for methyl tert-butyl ether analysis in water samples by use of solid phase microextraction and gas chromatography-mass spectrometry.
August 2001, Chemosphere,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Quantification of Seven Terpenes in Human Serum by Headspace Solid-Phase Microextraction-Gas Chromatography-Tandem Mass Spectrometry.
November 2020, Environmental science & technology,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Determination of acrolein by headspace solid-phase microextraction gas chromatography and mass spectrometry.
July 2001, Journal of chromatography. B, Biomedical sciences and applications,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Determination of pyrimethanil and kresoxim-methyl in soils by headspace solid-phase microextraction and gas chromatography-mass spectrometry.
August 2004, Analytical and bioanalytical chemistry,
Rui Zhang, and Yong Mei, and Yanru Liu, and Hao Dai, and Hongfang Xia, and Xin Zhang, and Yukang Wu, and Yingying Gu, and Xiaowu Peng
Simultaneous determination of selegiline and desmethylselegiline in human body fluids by headspace solid-phase microextraction and gas chromatography-mass spectrometry.
December 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,
Copied contents to your clipboard!