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Few studies have reported the use of double-filtration plasmapheresis (DFPP) in antibody-incompatible kidney transplantation. To assess the efficiency and tolerability of DFPP, we prospectively studied four chronic hemodialysis patients from two centers undergoing antibody-incompatible kidney transplantation. DFPP was used for ABO-incompatible transplantation (n = 1), for high human leukocyte antigen (HLA) immunization levels (n = 2) or for the presence of a donor-specific antibody (DSA) against a potential living donor (n = 1). In all the patients, the DFPP program was discontinued because of the adverse effects. Low blood pressure occurred during the first hour of the session in all the patients. A significant loss of plasma proteins, clotting factors and immunoglobulins also occurred during this treatment. In addition, fistula thrombosis was diagnosed in two patients. Three patients experienced gastrointestinal symptoms. The DFPP reduced the titers of the anti-B antibodies and reduced the levels of DSA in one patient, but had no effect on anti-HLA antibodies in the remaining two patients. Our study highlights the non-tolerability and poor efficacy of DFPP prior to antibody-incompatible kidney transplantation that limit its extensive use in the desensitization protocols.
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
August 2010,
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
December 2018,
Transplantation proceedings,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
October 2014,
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
April 1998,
Clinical transplantation,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
April 2023,
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
April 2015,
Journal of the Formosan Medical Association = Taiwan yi zhi,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
January 2003,
Gynecologic and obstetric investigation,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
February 2003,
Transplantation proceedings,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
November 2005,
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA,
Hadia Hebibi, and
Hugo Weclawiak, and
Lionel Rostaing, and
Séverine Beaudreuil, and
Asma Allal, and
Hélène François, and
Antoine Durrbach, and
Nassim Kamar
December 2007,
Transplantation,
