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Stereoselective nickel-catalyzed [2+2] cycloadditions of ene-allenes. 2015

Njamkou N Noucti, and Erik J Alexanian
Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA).

A stereoselective nickel-catalyzed [2+2] cycloaddition of ene-allenes is reported. This transformation encompasses a broad range of ene-allene substrates, thus providing efficient access to fused cyclobutanes from easily accessed π-components. A simple and inexpensive first-row catalytic system comprised of [Ni(cod)2 ] and dppf was used in this process, thus constituting an attractive approach to synthetically challenging cyclobutane frameworks under mild reaction conditions.

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