Biomaterial Database

Flow-dependent regulation of coronary vasomotor tone. 1989

E Bassenge

Institute of Applied Physiology, University of Freiburg, F.R.G.

Large coronary artery calibres are regulated by humoral factors (autacoids) released from the endothelial cell lining. Several hormones, transmitters and platelet-derived products like serotonin and ATP or acetylcholine, noradrenaline, and histamine, stimulate such an autacoid release and thus an endothelium-mediated dilation in addition to their direct constrictor effect on the vasculature. Another mechanical stimulus is the flow-induced shear stress acting as viscous drag upon the endothelial surface along with the pulsatile stretching of the endothelial lining, which causes, in a moment to moment fashion, a continuous adjustment of coronary calibres. With endothelial function impaired or absent as in atheromatosis or after balloon catheter denudation this adjustment is compromised. Thus unbalanced constrictor effects may become effective especially in the presence of a simultaneously reduced platelet antiaggregation.

UI	MeSH Term	Description	Entries
D009129	Muscle Tonus	The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)	Muscle Tension,Muscle Tightness,Muscular Tension,Tension, Muscle,Tension, Muscular,Tightness, Muscle,Tonus, Muscle
D011673	Pulsatile Flow	Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.	Flow, Pulsating,Perfusion, Pulsatile,Flow, Pulsatile,Flows, Pulsatile,Flows, Pulsating,Perfusions, Pulsatile,Pulsatile Flows,Pulsatile Perfusion,Pulsatile Perfusions,Pulsating Flow,Pulsating Flows
D003326	Coronary Circulation	The circulation of blood through the CORONARY VESSELS of the HEART.	Circulation, Coronary
D003331	Coronary Vessels	The veins and arteries of the HEART.	Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D004730	Endothelium, Vascular	Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.	Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012898	Autacoids	A chemically diverse group of substances produced by various tissues in the body that cause slow contraction of smooth muscle; they have other intense but varied pharmacologic activities.	Autacoid,Slow-Reacting Substance,Slow-Reacting Substances,Slow Reacting Substance,Slow Reacting Substances,Substance, Slow-Reacting,Substances, Slow-Reacting