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After allogeneic bone marrow transplantation (BMT), patient hematopoietic and lymphoid cells are replaced by cells derived from the donor marrow. To document and characterize successful engraftment, host and donor cells must be distinguished from each other. We have used DNA sequence polymorphism analysis in 6 patients, at times varying, to determine reliably the host or donor origin of posttransplant cell populations and to compare these results with those obtained using red blood cell antigens and cytogenetics. Initially full engraftment was documented in all patients. In 1 patient a mixed lymphohematopoietic chimerism was documented 6 months after BMT and it reverted to donor hematopoiesis at 1 year post BMT. Posttransplant leukemic relapse was studied in two patients and shown to be of host origin in both cases. The DNA restriction fragment length polymorphisms (RFLP), are a powerful tool for the documentation of engraftment after BMT, to document mixed lymphohematopoietic chimerism and for the evaluation of leukemic relapse.
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
October 2005,
Clinical transplantation,
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
February 1986,
Cancer genetics and cytogenetics,
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
December 1985,
Blood,
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
January 1997,
The Turkish journal of pediatrics,
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
March 1997,
Clinics in laboratory medicine,
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
June 1989,
The New England journal of medicine,
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
May 1993,
Leukemia,
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
August 1994,
Transplantation proceedings,
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
April 1988,
Lancet (London, England),
S Brunet, and
T Casals, and
P Madoz, and
A Aventín, and
E Muñiz, and
M Baiget
January 1980,
Pathologie-biologie,
