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Thirty clones producing monoclonal antibodies (MCAs) to rat visceral yolk sac (VYS) antigens have been prepared. These MCAs localized by immunofluorescence in the VYS endoderm in vitro and were tested for developmental toxicity by intraperitioneal injection of ascites fluid into pregnant rats on day 9 of gestation. Five of the hybridomas produced MCAs that induced embryonic death, malformation, and growth retardation; the other MCAs had no developmental toxicity. Five MCAs, three teratogenic and two nonteratogenic, were tested for their ability to inhibit pinocytosis in the isolated day 17-VYS. Only the teratogenic MCAs were inhibitory, providing further evidence for the hypothesis that teratogenic antibodies interfere with the nutritional supply to the embryo.
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
June 1984,
International journal of cancer,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
February 1985,
International journal of cancer,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
January 2005,
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
September 1984,
Nihon Jinzo Gakkai shi,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
January 1992,
Acta anatomica,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
June 1971,
The British journal of venereal diseases,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
September 1997,
Placenta,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
December 2001,
Immunological reviews,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
November 1988,
Acta endocrinologica,
M Jensen, and
J B Lloyd, and
T R Koszalka, and
D A Beckman, and
R L Brent
March 1990,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
