Biomaterial Database

Pharmacokinetic and pharmacodynamic implications in inhalable antimicrobial therapy. 2015

Jatinder Kaur Mukker, and Ravi Shankar Prasad Singh, and Hartmut Derendorf

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610-0494, USA.

Inhaled antimicrobials provide a promising alternative to the systemically delivered drugs for the treatment of acute and chronic lung infections. The delivery of antimicrobials via inhalation route decreases the systemic exposure while increasing the local concentration in the lungs, enabling the use of antimicrobials with severe systemic side effects. The inhalation route of administration has several challenges in pharmacokinetic (PK) and pharmacodynamic (PD) assessments. This review discusses various issues that need to be considered during study, data analysis, and interpretation of PK and PD of inhaled antimicrobials. Advancements overcoming the challenges are also discussed.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000280	Administration, Inhalation	The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.	Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000900	Anti-Bacterial Agents	Substances that inhibit the growth or reproduction of BACTERIA.	Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D016503	Drug Delivery Systems	Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.	Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug

Related Publications

Jatinder Kaur Mukker, and Ravi Shankar Prasad Singh, and Hartmut Derendorf

Sequential antimicrobial therapy: pharmacokinetic and pharmacodynamic considerations in sequential therapy.

July 1998, The Journal of infection,

Jatinder Kaur Mukker, and Ravi Shankar Prasad Singh, and Hartmut Derendorf

Pharmacokinetic and pharmacodynamic considerations in antimicrobial therapy for sepsis.

May 2020, Expert opinion on drug metabolism & toxicology,

Jatinder Kaur Mukker, and Ravi Shankar Prasad Singh, and Hartmut Derendorf

Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters.

November 2001, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,

Jatinder Kaur Mukker, and Ravi Shankar Prasad Singh, and Hartmut Derendorf

Collaborative Pharmacokinetic-Pharmacodynamic Research for Optimization of Antimicrobial Therapy.

September 2016, Infection & chemotherapy,

Jatinder Kaur Mukker, and Ravi Shankar Prasad Singh, and Hartmut Derendorf

Pharmacokinetic and pharmacodynamic issues for antimicrobial therapy in patients with cancer.

June 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,

Jatinder Kaur Mukker, and Ravi Shankar Prasad Singh, and Hartmut Derendorf

Selecting antibacterials for outpatient parenteral antimicrobial therapy : pharmacokinetic-pharmacodynamic considerations.

January 2003, Clinical pharmacokinetics,

Jatinder Kaur Mukker, and Ravi Shankar Prasad Singh, and Hartmut Derendorf

Modulite technology: pharmacodynamic and pharmacokinetic implications.

August 2002, Respiratory medicine,