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To study the antigenic characteristics of respiratory syncytial virus (RSV), we developed and evaluated monoclonal antibodies (MAbs) to three strains of RSV: 11 to Long, 4 to 18537, and 9 to A2. Six of these MAbs immunoprecipitated the nucleoprotein, six the large glycoprotein, and 11 the fusion protein. By the pattern of the reactions of these MAbs to 16 strains of RSV in an indirect immunofluorescence assay or enzyme-linked immunosorbent assay, we were able to distinguish three subgroups. With a panel of 10 of these 24 MAbs, we tested 26 strains isolated between 1979 and 1982 in Boston and found that 22 belonged to group 1, 4 to group 2, and none to group 3. The pattern of the reactions of the MAbs against representative strains from the three groups identified nine epitopes by indirect immunofluorescence assay: three of each on the nucleoprotein, the large glycoprotein, and the fusion protein. These results, along with those of previous studies, suggest that groups 1 and 3 are antigenically similar and group 2 is antigenically more distinct.
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
June 1999,
The Pediatric infectious disease journal,
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
December 1988,
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L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
February 1995,
Veterinary microbiology,
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
January 1984,
Developments in biological standardization,
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
April 1963,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
June 1988,
Veterinary immunology and immunopathology,
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
October 1983,
Lancet (London, England),
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
December 1990,
The Journal of general virology,
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
September 1992,
The Journal of general virology,
L J Anderson, and
J C Hierholzer, and
C Tsou, and
R M Hendry, and
B F Fernie, and
Y Stone, and
K McIntosh
May 2021,
The Pediatric infectious disease journal,
