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The hypothesis of cyclooxygenase derivates of arachidonic acid as putative mediators of late phase skin reactions (LPR) was evaluated by studying the effect of indomethacin and naproxen on anti-IgE elicited skin reactions in healthy volunteers. Indomethacin 50 mg t.i.d., 48 h prior to and up to 24 h following challenge with anti-IgE 1/3300 (v/v), produced a slight attenuation of the flare response and a 35% inhibition of the LPR (P less than 0.05) at 1-24 h as compared with placebo (n = 11). Naproxen, 250 mg, b.i.d. showed analogous anti-LPR effect (n = 4, P less than 0.05). Intradermally (i.d.) injected indomethacin, 75 micrograms (7 X 10(-3) mol/l), attenuated the flare and LPR to anti-IgE 1/330 at 1-6 h (n = 12, P less than 0.01). Indomethacin, oral and i.d., enhanced the LPR to various dilutions of anti-IgE in 30% of the individuals. The results suggest that prostaglandins and thromboxanes participate in the development of an LPR in human skin.
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R Grönneberg, and
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