-transparent.png){kind=logo}
The effects of antigastrin (SC-15396) on amylase release and 2-deoxyglucose uptake were studied in dispersed acini from mouse pancreas. Antigastrin at concentrations between 0.5 and 2 mM inhibited cholecystokinin (CCK)-stimulated amylase release and 2-deoxyglucose uptake in a dose-dependent fashion. Antigastrin at concentrations between 0.5 and 2 mM inhibited carbachol-stimulated amylase release and 2-deoxyglucose uptake as well. In addition, the drug (2 mM) inhibited bombesin-stimulated amylase release and 2-deoxyglucose uptake. In contrast, the stimulation of amylase release by Ca2+ ionophore A23187 was not inhibited by antigastrin. The results, therefore, suggest that antigastrin nonselectively inhibits the actions of these secretagogues probably at their receptor sites.
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
November 1971,
Horumon to rinsho. Clinical endocrinology,
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
January 1968,
Federation proceedings,
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
January 1992,
Diabetes research and clinical practice,
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
November 1991,
Biochemical and biophysical research communications,
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
June 1968,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
February 1986,
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine,
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
December 1985,
Scandinavian journal of gastroenterology,
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
November 1981,
The American journal of physiology,
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
June 1979,
The American journal of physiology,
Y Iwamoto, and
R Nakamura, and
Y Akanuma, and
T Kuzuya
May 2002,
The Journal of biological chemistry,
