An abnormal GABAergic system in the inferior colliculus provides a basis for audiogenic seizures in genetically epilepsy-prone rats. 2017

Charles E Ribak
Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, CA 92697-1275, USA. Electronic address: ribak@uci.edu.

In this review of neuroanatomical studies of the genetically epilepsy-prone rat (GEPR), three main topics will be covered. First, the number of GABAergic neurons and total neurons in the inferior colliculus of GEPRs will be compared to those of the nonepileptic Sprague-Dawley rat. Next, the number of small neurons in the inferior colliculus will be described in both developmental and genetic analyses of GEPRs and their backcrosses. Last, results from two types of studies on the propagation pathways for audiogenic seizures in GEPRs will be shown. Together, these studies demonstrate a unique GABAergic, small neuron defect in the inferior colliculus of GEPRs that may play a vital role in the initiation and spread of seizure activity during audiogenic seizures. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".

UI MeSH Term Description Entries
D007245 Inferior Colliculi The posterior pair of the quadrigeminal bodies which contain centers for auditory function. Colliculus, Inferior,Brachial Nucleus of the Inferior Colliculus,Caudal Colliculus,Colliculus Inferior,Inferior Colliculus,Posterior Colliculus,Colliculi, Inferior,Colliculus Inferiors,Colliculus, Caudal,Colliculus, Posterior,Inferior, Colliculus,Inferiors, Colliculus
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012640 Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder." Absence Seizure,Absence Seizures,Atonic Absence Seizure,Atonic Seizure,Clonic Seizure,Complex Partial Seizure,Convulsion,Convulsions,Convulsive Seizure,Convulsive Seizures,Epileptic Seizure,Epileptic Seizures,Generalized Absence Seizure,Generalized Tonic-Clonic Seizures,Jacksonian Seizure,Myoclonic Seizure,Non-Epileptic Seizure,Nonepileptic Seizure,Partial Seizure,Seizure,Seizures, Convulsive,Seizures, Focal,Seizures, Generalized,Seizures, Motor,Seizures, Sensory,Tonic Clonic Seizure,Tonic Seizure,Tonic-Clonic Seizure,Atonic Absence Seizures,Atonic Seizures,Clonic Seizures,Complex Partial Seizures,Convulsion, Non-Epileptic,Generalized Absence Seizures,Myoclonic Seizures,Non-Epileptic Seizures,Nonepileptic Seizures,Partial Seizures,Petit Mal Convulsion,Seizures, Auditory,Seizures, Clonic,Seizures, Epileptic,Seizures, Gustatory,Seizures, Olfactory,Seizures, Somatosensory,Seizures, Tonic,Seizures, Tonic-Clonic,Seizures, Vertiginous,Seizures, Vestibular,Seizures, Visual,Single Seizure,Tonic Seizures,Tonic-Clonic Seizures,Absence Seizure, Atonic,Absence Seizure, Generalized,Absence Seizures, Atonic,Absence Seizures, Generalized,Auditory Seizure,Auditory Seizures,Clonic Seizure, Tonic,Clonic Seizures, Tonic,Convulsion, Non Epileptic,Convulsion, Petit Mal,Convulsions, Non-Epileptic,Focal Seizure,Focal Seizures,Generalized Seizure,Generalized Seizures,Generalized Tonic Clonic Seizures,Generalized Tonic-Clonic Seizure,Gustatory Seizure,Gustatory Seizures,Motor Seizure,Motor Seizures,Non Epileptic Seizure,Non Epileptic Seizures,Non-Epileptic Convulsion,Non-Epileptic Convulsions,Olfactory Seizure,Olfactory Seizures,Partial Seizure, Complex,Partial Seizures, Complex,Seizure, Absence,Seizure, Atonic,Seizure, Atonic Absence,Seizure, Auditory,Seizure, Clonic,Seizure, Complex Partial,Seizure, Convulsive,Seizure, Epileptic,Seizure, Focal,Seizure, Generalized,Seizure, Generalized Absence,Seizure, Generalized Tonic-Clonic,Seizure, Gustatory,Seizure, Jacksonian,Seizure, Motor,Seizure, Myoclonic,Seizure, Non-Epileptic,Seizure, Nonepileptic,Seizure, Olfactory,Seizure, Partial,Seizure, Sensory,Seizure, Single,Seizure, Somatosensory,Seizure, Tonic,Seizure, Tonic Clonic,Seizure, Tonic-Clonic,Seizure, Vertiginous,Seizure, Vestibular,Seizure, Visual,Seizures, Generalized Tonic-Clonic,Seizures, Nonepileptic,Sensory Seizure,Sensory Seizures,Single Seizures,Somatosensory Seizure,Somatosensory Seizures,Tonic Clonic Seizures,Tonic-Clonic Seizure, Generalized,Tonic-Clonic Seizures, Generalized,Vertiginous Seizure,Vertiginous Seizures,Vestibular Seizure,Vestibular Seizures,Visual Seizure,Visual Seizures
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D059330 GABAergic Neurons Neurons whose primary neurotransmitter is GAMMA-AMINOBUTYRIC ACID. GABA Cells,GABA Neurons,Cell, GABA,Cells, GABA,GABA Cell,GABA Neuron,GABAergic Neuron,Neuron, GABA,Neuron, GABAergic,Neurons, GABA,Neurons, GABAergic
D020195 Epilepsy, Reflex A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8) Reflex Epilepsy,Reflex Epilepsy, Audiogenic,Reflex Epilepsy, Cursive (Running),Reflex Epilepsy, Eating-Induced,Reflex Epilepsy, Musicogenic,Reflex Epilepsy, Photosensitive,Reflex Epilepsy, Reading,Audiogenic Epilepsy,Cursive Epilepsy,Decision Making Reflex Epilepsy,Eating-Induced Epilepsy,Epilepsy, Photogenic,Epilepsy, Reading,Immersion Related Epilepsy,Musicogenic Epilepsy,Photosensitive Epilepsy,Reading Epilepsy,Reflex Epilepsy, Visual Pattern,Tactile Reflex Epilepsy,Visual Pattern Reflex Epilepsy,Writing-Induced Reflex Epilepsy,Audiogenic Epilepsies,Audiogenic Reflex Epilepsies,Audiogenic Reflex Epilepsy,Cursive Reflex Epilepsies (Running),Cursive Reflex Epilepsy (Running),Eating Induced Epilepsy,Eating-Induced Epilepsies,Eating-Induced Reflex Epilepsies,Eating-Induced Reflex Epilepsy,Epilepsies, Audiogenic Reflex,Epilepsies, Cursive,Epilepsies, Eating-Induced,Epilepsies, Eating-Induced Reflex,Epilepsies, Immersion Related,Epilepsies, Musicogenic,Epilepsies, Musicogenic Reflex,Epilepsies, Photosensitive,Epilepsies, Photosensitive Reflex,Epilepsies, Reading,Epilepsies, Reading Reflex,Epilepsies, Reflex,Epilepsies, Tactile Reflex,Epilepsies, Writing-Induced Reflex,Epilepsy, Audiogenic,Epilepsy, Audiogenic Reflex,Epilepsy, Cursive,Epilepsy, Cursive Reflex (Running),Epilepsy, Eating-Induced,Epilepsy, Eating-Induced Reflex,Epilepsy, Immersion Related,Epilepsy, Musicogenic,Epilepsy, Musicogenic Reflex,Epilepsy, Photosensitive,Epilepsy, Photosensitive Reflex,Epilepsy, Reading Reflex,Epilepsy, Tactile Reflex,Epilepsy, Writing-Induced Reflex,Immersion Related Epilepsies,Musicogenic Epilepsies,Musicogenic Reflex Epilepsies,Musicogenic Reflex Epilepsy,Photosensitive Epilepsies,Photosensitive Reflex Epilepsies,Photosensitive Reflex Epilepsy,Reading Epilepsies,Reading Reflex Epilepsies,Reading Reflex Epilepsy,Reflex Epilepsies,Reflex Epilepsies, Audiogenic,Reflex Epilepsies, Cursive (Running),Reflex Epilepsies, Eating-Induced,Reflex Epilepsies, Musicogenic,Reflex Epilepsies, Photosensitive,Reflex Epilepsies, Reading,Reflex Epilepsies, Tactile,Reflex Epilepsies, Writing-Induced,Reflex Epilepsy, Eating Induced,Reflex Epilepsy, Tactile,Reflex Epilepsy, Writing-Induced,Tactile Reflex Epilepsies,Writing Induced Reflex Epilepsy,Writing-Induced Reflex Epilepsies

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