The effect of CO2 laser treatment on skin tissue. 2015

Sana Mohammed Anayb Baleg, and Noriah Bidin, and Lau Pik Suan, and Muhammad Fakarruddin Sidi Ahmad, and Ganesan Krishnan, and Abd Rahman Johari, and Asma Hamid
Laser Center, Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.

OBJECTIVE The aim of this study was to evaluate the effects of multiple pulses on the depth of injury caused by CO2 laser in an in vivo rat model. METHODS A 10 600-nm CO2 laser was applied to rat skin, with one side of the rat dorsal skin being exposed, leaving the other side as a control. RESULTS All of the various laser pulses tested led to gradual loss of epidermal thickness as well as a dramatic increase in thermal damage depth. Collagen coagulation was most effective with ten pulses of CO2 laser, while the strength of irradiated skin tissue increased as the influence of the laser increased. CONCLUSIONS Fundamental laser-skin interaction effects were studied using a CO2 laser. The photodamaged areas obtained from laser interaction were recorded via couple charge device video camera and analyzed via ImageJ software. Photodamage induced by CO2 laser is due to photothermal effects, which involve burning and vaporizing mechanisms to ablate the epidermis layer. The burning area literally expands and penetrates deep into the dermis layer, subsequently causing collagen coagulation. This fundamental study shows in detail the effect of CO2 laser interaction with skin. The CO2 attributed severe burning, producing deep coagulation, and induced strength to treated skin.

UI MeSH Term Description Entries
D008297 Male Males
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D004817 Epidermis The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012867 Skin The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D013718 Tensile Strength The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001) Strength, Tensile,Strengths, Tensile,Tensile Strengths
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D054020 Lasers, Gas Lasers in which a gas lasing medium is stimulated to emit light by an electric current or high-frequency oscillator. Argon Ion Lasers,CO2 Lasers,Carbon Dioxide Lasers,Copper Vapor Lasers,Gas Lasers,Gold Vapor Lasers,Helium Lasers,Helium Neon Gas Lasers,Metal Vapor Lasers,Nitrogen Lasers,Xenon Ion Lasers,HeNe Lasers,Lasers, Argon Ion,Lasers, CO2,Lasers, Carbon Dioxide,Lasers, Copper Vapor,Lasers, Gold Vapor,Lasers, Helium,Lasers, Helium Neon Gas,Lasers, Metal Vapor,Lasers, Nitrogen,Lasers, Xenon Ion,Argon Ion Laser,CO2 Laser,Carbon Dioxide Laser,Copper Vapor Laser,Dioxide Laser, Carbon,Dioxide Lasers, Carbon,Gas Laser,Gold Vapor Laser,HeNe Laser,Helium Laser,Ion Laser, Argon,Ion Laser, Xenon,Ion Lasers, Argon,Ion Lasers, Xenon,Laser, Argon Ion,Laser, CO2,Laser, Carbon Dioxide,Laser, Copper Vapor,Laser, Gas,Laser, Gold Vapor,Laser, HeNe,Laser, Helium,Laser, Metal Vapor,Laser, Nitrogen,Laser, Xenon Ion,Lasers, HeNe,Metal Vapor Laser,Nitrogen Laser,Vapor Laser, Copper,Vapor Laser, Gold,Vapor Laser, Metal,Vapor Lasers, Copper,Vapor Lasers, Gold,Vapor Lasers, Metal,Xenon Ion Laser
D023421 Models, Animal Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing. Experimental Animal Models,Laboratory Animal Models,Animal Model,Animal Model, Experimental,Animal Model, Laboratory,Animal Models,Animal Models, Experimental,Animal Models, Laboratory,Experimental Animal Model,Laboratory Animal Model,Model, Animal,Model, Experimental Animal,Model, Laboratory Animal,Models, Experimental Animal,Models, Laboratory Animal

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