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Antibodies to BK virus in children prior to allogeneic hematopoietic cell transplant. 2015
Benjamin L Laskin, and
Kathleen E Sullivan, and
Jeff Hester, and
Jens Goebel, and
Stella M Davies, and
Sonata Jodele
Division of Nephrology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
BK virus (BKV) is associated with kidney and bladder disease after hematopoietic cell transplantation (HCT) but less is known about the seroprevalence of pre-transplant antibodies to BKV in children. We measured BKV IgG antibody titers in 36 children before HCT. BKV IgG antibodies were detected in all 36 patients, with 28/36 (77.8%) developing BK viremia in the first 100 days. Pre-HCT BKV IgG antibody titers >1:40,960 were protective against later BK viremia ≥10,000 copies/ml. The seroprevalence of antibodies to BKV is high in children undergoing HCT and post-transplant BK viremia, which is associated with bladder and kidney injury, is common.
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