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Fifty-eight isochromosomal lines sampled from two natural populations of Drosophila pseudoobscura in California and one from Bogota, Colombia, were examined using four-cutter restriction mapping. A 4.6-kb region of the xanthine dehydrogenase locus was probed and 66 of 135 restriction sites scored were polymorphic. This predicts that on average every 12th bp would be polymorphic in this region for the genes surveyed if polymorphism occurred randomly along the coding region. In addition, there were 12 insertion/deletion polymorphisms. Forty-nine distinct haplotypes were recognized in the 58 lines examined. The most common haplotype obtained a frequency of only 5%. Measures of base pair heterozygosity (0.0097) and linkage disequilibrium lead to a predicted population size in the range of 1.2-2.4 X 10(6) for the species. High levels of recombination (including gene conversion) can be inferred from the presence of all four gametic types in the data set.
M A Riley, and
M E Hallas, and
R C Lewontin
October 1978,
Proceedings of the National Academy of Sciences of the United States of America,
M A Riley, and
M E Hallas, and
R C Lewontin
February 1986,
Genetics,
M A Riley, and
M E Hallas, and
R C Lewontin
January 1992,
Molecular biology and evolution,
M A Riley, and
M E Hallas, and
R C Lewontin
April 1971,
Genetics,
M A Riley, and
M E Hallas, and
R C Lewontin
July 1979,
Genetics,
M A Riley, and
M E Hallas, and
R C Lewontin
September 1995,
Genetics,
M A Riley, and
M E Hallas, and
R C Lewontin
January 1976,
Genetics,
M A Riley, and
M E Hallas, and
R C Lewontin
November 1996,
Genetics,
M A Riley, and
M E Hallas, and
R C Lewontin
September 1977,
Genetics,
M A Riley, and
M E Hallas, and
R C Lewontin
January 1981,
Genetics,
