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Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses. 2015
Shanmugam Saravanan, and
Selvamurthi Gomathi, and
Bagavathi Kausalya, and
Jayaseelan Boobalan, and
Kailapuri G Murugavel, and
Pachamuthu Balakrishnan, and
Sarvode N Mothi, and
Sunil S Solomon, and
Nagalingeswaran Kumarasamy, and
Poongulali Selvamuthu, and
Suniti Solomon, and
Davey M Smith
1YRG CARE, Chennai, India.
In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.
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