N-stearoyltyrosine dipotassium ameliorates high-fat diet-induced obesity in C57BL/6 mice. 2015

Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

N-stearoyltyrosine dipotassium (NST-2K) as a neuroprotective candidate is currently in preclinical studies in China. This study investigated the anti-obese effect of NST-2K in high-fat diet-induced obese (DIO) mice. The DIO mice were induced from male C57BL/6 mice by feeding high-fat diet for 11-weeks and treated orally with NST-2K for other 4 weeks. The treatments of DIO mice with NST-2K at 60 or 100 mg/kg/day suppressed the body weight gain, decreased both visceral fat weight and adipocyte size without influence on food intake. To evaluate the effect of NST-2K on lipid metabolism, lipid parameters and several key molecules in the plasma, liver, duodenum mucosa and adipose tissue were analyzed. NST-2K ameliorated the low-grade inflammation in liver, inhibited pancreatic lipase activity in duodenum mucosa, activated β-oxidation system and reduced lipogenesis, thus suppressed lipid accumulation in the liver, reduced adipocyte size and improved lipid and carbohydrate metabolism. Overall, without influence on food intake, NST-2K ameliorated high-fat diet-induced obesity via suppressing liver inflammation, inhibiting dietary fat absorption, promoting lipolysis and reducing lipogenesis.

UI MeSH Term Description Entries
D007408 Intestinal Absorption Uptake of substances through the lining of the INTESTINES. Absorption, Intestinal
D007413 Intestinal Mucosa Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI. Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D008049 Lipase An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3. Triacylglycerol Lipase,Tributyrinase,Triglyceride Lipase,Acid Lipase,Acid Lipase A,Acid Lipase B,Acid Lipase I,Acid Lipase II,Exolipase,Monoester Lipase,Triacylglycerol Hydrolase,Triglyceridase,Triolean Hydrolase,Hydrolase, Triacylglycerol,Hydrolase, Triolean,Lipase A, Acid,Lipase B, Acid,Lipase I, Acid,Lipase II, Acid,Lipase, Acid,Lipase, Monoester,Lipase, Triglyceride
D008066 Lipolysis The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues. Lipolyses
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D004041 Dietary Fats Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados. Fats, Dietary,Dietary Fat,Fat, Dietary

Related Publications

Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
January 2022, Frontiers in endocrinology,
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
January 2012, Food & function,
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
February 2017, Nutrients,
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
January 2023, Phytotherapy research : PTR,
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
October 2019, Nutrients,
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
January 2020, BioMed research international,
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
February 2020, Food science and biotechnology,
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
April 2024, Obesity (Silver Spring, Md.),
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
January 2015, American journal of translational research,
Shuang-Qi Tang, and Sha Yin, and Sha Liu, and Ke-Jia Le, and Ruo-Lin Yang, and Jian-Hua Liu, and Xiao-Lin Wang, and Zhao-Xi Zheng, and Lin Zheng, and Qiang Lin, and Yang Lu
October 2020, Nutrients,
Copied contents to your clipboard!